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New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure
Date:5/8/2009

, headache (4 patients, 2.2%), and hypotension (4 patients, 2.2%). Among individual treatment regimens, headache (4 patients, 2.4%) and dizziness (4 patients, 2.4%) were reported for OM 40 mg and dizziness (6 patients, 3.8%) was reported for OM/HCTZ 40/12.5 mg. Nine patients (5.1%) discontinued participation in the study due to TEAE.

The results of this open-label trial differ from those obtained in the pivotal, placebo-controlled US MATRIX trial.

About BENICAR(R) and BENICAR HCT(R)

Angiotensin II is a hormone that interacts with a receptor on arterial blood vessels, which results in constriction and increasing blood pressure. In addition, angiotensin II stimulates the release of another hormone that causes enhanced sodium and chloride (salt) retention, with a resultant increase in vascular water retention and blood volume that also contributes to an elevation in blood pressure. BENICAR is a member of the ARB class of antihypertensive medications that help lower blood pressure by blocking the angiotensin II receptor on the blood vessels and antagonizing the release of the hormone which causes salt retention and increased blood volume. BENICAR HCT(R) combines BENICAR(R) with the diuretic hydrochlorothiazide.

BENICAR and BENICAR HCT are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertensive agents. BENICAR HCT is not indicated for initial therapy.

IMPORTANT SAFETY INFORMATION ABOUT BENICAR(R) and BENICAR HCT(R)

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, BENICAR or BENICAR HCT should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidi
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SOURCE Daiichi Sankyo, Inc.
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