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New Data Show TORISEL Improves Progression-Free Survival for Patients With Relapsed/Refractory Mantle Cell Lymphoma
Date:5/31/2008

- Data From Phase 3 Study Presented at ASCO -

COLLEGEVILLE, Pa., May 31 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), today announced results of a three-arm phase 3 clinical trial that show patients with relapsed and/or refractory mantle cell lymphoma (MCL), a form of non-Hodgkin's lymphoma, treated with the mTOR (mammalian target of rapamycin) inhibitor TORISEL(R) (temsirolimus) experienced a statistically significant improvement in median progression-free survival (PFS), compared with single-agent therapy selected by the investigator (4.8 months vs. 1.9 months, P=0.0009). These results are being presented at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

"Relapsed/refractory mantle cell lymphoma is extremely difficult to treat, and this is the first comparative phase 3 study to show a significant improvement in progression-free survival for these patients," says Georg Hess, M.D., Johannes Gutenberg-Universitat, Mainz, Germany. "These data further support the antitumor activity seen in phase 2 studies of temsirolimus in relapsed/refractory mantle cell lymphoma and indicate that mTOR inhibition may be a viable approach in this disease area."

MCL accounts for approximately 6 percent of non-Hodgkin's lymphoma cases.

"These findings reinforce the clinical potential of mTOR inhibition with TORISEL. Wyeth is committed to the continued exploration of mTOR inhibition with TORISEL for the treatment of a variety of cancers," says Joseph S. Camardo, M.D., Senior Vice President, Global Medical Affairs, Wyeth Pharmaceuticals.

TORISEL was approved in May 2007 for the treatment of advanced renal cell carcinoma (RCC) and is the only
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