Navigation Links
New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria
Date:10/27/2008

riteria. Overall, the Enterobacteriaceae doripenem-susceptibility rate (less than or equal to 0.5 micrograms/mL) was 98.9%. ESBLs were detected in 5.7, 17.3 and 4.8% of E. coli, Klebsiella spp. and P. mirabilis, respectively; AmpC-production rates were 1.6, 23.7, 2.2 and 2.7% for Citrobacter spp., Enterobacter spp., indole-positive Proteae and Serratia spp. ESBL and AmpC enzymes had little impact on doripenem MIC(50) potencies (up to two-fold). Sporadic occurrence of Bush group 2f carbapenemases (KPC) among Klebsiella spp. was detected along with rare metallo-Beta-lactamases in other Enterobacteriaceae, elevating carbapenem MICs.

About Extended-spectrum Beta-lactamases (ESBLs)

A type of Enterobacteriaceae, extended-spectrum Beta-lactamases (ESBLs) are a growing concern for physicians treating hospitalized patients. Infection with ESBLs are especially prevalent in intensive care units (ICUs) and are associated with high rates of morbidity and mortality, prolonged hospital stay and higher costs. ESBLs represent a significant threat in the infectious diseases field.

About DORIBAX(TM) (doripenem for injection)

DORIBAX is an intravenous (IV) antibiotic for hospital use, and belongs to a class of antibacterial drugs called carbapenems. Carbapenems are important antibiotics to treat serious - and often life-threatening - infections caused by a broad range of bacteria.

DORIBAX was approved in the U.S. in October 2007 for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI), including pyelonephritis, due to susceptible bacteria, and is marketed by Ortho-McNeil, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. DORIBAX is also approved in the EU and Russia for cIAI, cUTI and NP, including VAP. Doripenem is licensed from Shionogi & Co., Ltd.

INDICATIONS

DORIBAX(TM) (doripenem for injection) is indicated as a single agent for the treatment of:

-- Compli
'/>"/>

SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Georgia Reproductive Specialists Participates in Largest-Ever In Vitro Fertilization Clinical Trial in the World
2. Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria
3. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
4. Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria
5. MatTeks EpiDerm In Vitro Tissues Headed for Validation in Europe
6. Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
7. Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival
8. New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias
9. Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza
10. Molnlycke Drives Home the Fight Against Staph and Other MRSA Infections
11. Mayo Clinic Study Finds FDA Warning Against Anti-Nausea Drug Droperidol Unnecessary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... SANTA ROSA, Calif. , Oct. 24, 2014 /PRNewswire-USNewswire/ ... he was ordering large quantities of multiple controlled substances, ... patient care. They also reported that Dr. Gurney was ... Medical Board reported that one of his employees said ... his care and treatment of patients." Dr. ...
(Date:10/25/2014)... , October 24, 2014 ... ) has announced the addition of the  ... 2014"  report to their offering.  ... and Chinese Acne Medication Industry Report 2014 ... the current state of the global acne ...
(Date:10/25/2014)... Oct. 24, 2014  As the building blocks ... company access to diverse skill sets and expertise, ... clock business hours for efficiency. However, effectively managing ... According to recent research, more than ... seeing a project not move forward due to ...
Breaking Medicine Technology:Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 2Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 3Global and Chinese Acne Medication Industry Report 2014 2Global and Chinese Acne Medication Industry Report 2014 3Work Around the Clock: Successfully Building & Managing Global Virtual Teams 2
(Date:10/25/2014)... HealthDay Reporter FRIDAY, Oct. ... cold sores -- herpes simplex -- might increase the risk ... In fact, being a carrier of certain antibodies to the ... found. "The identification of a treatable cause [herpes ... said lead researcher Dr. Hugo Lovheim, an associate professor in ...
(Date:10/25/2014)... Oct. 24, 2014 (HealthDay News) -- Researchers who ... their findings are cause for concern. The ... are raised for human consumption contribute to the ... according to background information from the study. ... sicken about 2 million people and kill about ...
(Date:10/25/2014)... FRIDAY, Oct. 23, 2014 (HealthDay News) -- Current ... many younger postmenopausal women at risk for osteoporosis-related ... want to prevent fractures, we need tools that ... osteoporotic injuries so that we can target these ... Carolyn Crandall, professor of medicine in the division ...
(Date:10/25/2014)... 2014 (HealthDay News) -- October,s shorter, darker days can ... disorder, according to an expert. People affected ... overly tired, lack motivation and even have trouble getting ... to suicide, said Dr. Angelos Halaris, a professor in ... University Chicago Stitch School of Medicine. "Seasonal affective ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 On Saturday, October ... its fourth annual family health and fitness fair ¡Vive tu ... physical activity and good nutrition for better health and wellness ... which is free and open to the public, will be ... Brownsville, from 9:00 am to 1:00 pm. , “¡Vive ...
Breaking Medicine News(10 mins):Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4
... (“bad” cholesterol) to below 100 milligrams per deciliter by ... safe and results in fewer cardiovascular events. ,The ... 10 milligrams of atorvastatin (Lipitor) a day to get ... a day or lower. Then, half of the patients ...
... have been conducted to see whether antihypertensive strategies ... // are superior to older treatments with beta-blockers ... calcium channel blocker amlodipine with or without the ... or without the diuretic bendroflumethiazide. ,The trial ...
... stem cell research that will help in numerous therapies using ... growing human embryonic stem cells in the laboratory. ... important role in regeneration of cells for therapeutic use. However, ... live animal cells and serum and run the risk of ...
... Medical Association, researchers have pointed out that there seems to ... the children resulting in increase in risk of the vaccinated ... study, most of the vaccines that need to be completed ... gets delayed due to a variety of reasons, most important ...
... cases of testicular cancer occur and it is the most ... than 90 percent of the cases can be cured, especially ... difficult to detect the cancer before it starts to spread. ... detecting testicular cancer before it spreads. ,Researchers say they ...
... ,Researchers led by Professor Julie Williams and Professor Michael O'Donovan ... to be the cause of dyslexia in children. An analysis ... from dyslexia was done to identify the gene. The gene ... breakthrough and the first study to identify one gene which ...
Cached Medicine News:
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: