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New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria
Date:10/27/2008

riteria. Overall, the Enterobacteriaceae doripenem-susceptibility rate (less than or equal to 0.5 micrograms/mL) was 98.9%. ESBLs were detected in 5.7, 17.3 and 4.8% of E. coli, Klebsiella spp. and P. mirabilis, respectively; AmpC-production rates were 1.6, 23.7, 2.2 and 2.7% for Citrobacter spp., Enterobacter spp., indole-positive Proteae and Serratia spp. ESBL and AmpC enzymes had little impact on doripenem MIC(50) potencies (up to two-fold). Sporadic occurrence of Bush group 2f carbapenemases (KPC) among Klebsiella spp. was detected along with rare metallo-Beta-lactamases in other Enterobacteriaceae, elevating carbapenem MICs.

About Extended-spectrum Beta-lactamases (ESBLs)

A type of Enterobacteriaceae, extended-spectrum Beta-lactamases (ESBLs) are a growing concern for physicians treating hospitalized patients. Infection with ESBLs are especially prevalent in intensive care units (ICUs) and are associated with high rates of morbidity and mortality, prolonged hospital stay and higher costs. ESBLs represent a significant threat in the infectious diseases field.

About DORIBAX(TM) (doripenem for injection)

DORIBAX is an intravenous (IV) antibiotic for hospital use, and belongs to a class of antibacterial drugs called carbapenems. Carbapenems are important antibiotics to treat serious - and often life-threatening - infections caused by a broad range of bacteria.

DORIBAX was approved in the U.S. in October 2007 for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI), including pyelonephritis, due to susceptible bacteria, and is marketed by Ortho-McNeil, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. DORIBAX is also approved in the EU and Russia for cIAI, cUTI and NP, including VAP. Doripenem is licensed from Shionogi & Co., Ltd.

INDICATIONS

DORIBAX(TM) (doripenem for injection) is indicated as a single agent for the treatment of:

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SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
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