Navigation Links
New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria
Date:10/27/2008

riteria. Overall, the Enterobacteriaceae doripenem-susceptibility rate (less than or equal to 0.5 micrograms/mL) was 98.9%. ESBLs were detected in 5.7, 17.3 and 4.8% of E. coli, Klebsiella spp. and P. mirabilis, respectively; AmpC-production rates were 1.6, 23.7, 2.2 and 2.7% for Citrobacter spp., Enterobacter spp., indole-positive Proteae and Serratia spp. ESBL and AmpC enzymes had little impact on doripenem MIC(50) potencies (up to two-fold). Sporadic occurrence of Bush group 2f carbapenemases (KPC) among Klebsiella spp. was detected along with rare metallo-Beta-lactamases in other Enterobacteriaceae, elevating carbapenem MICs.

About Extended-spectrum Beta-lactamases (ESBLs)

A type of Enterobacteriaceae, extended-spectrum Beta-lactamases (ESBLs) are a growing concern for physicians treating hospitalized patients. Infection with ESBLs are especially prevalent in intensive care units (ICUs) and are associated with high rates of morbidity and mortality, prolonged hospital stay and higher costs. ESBLs represent a significant threat in the infectious diseases field.

About DORIBAX(TM) (doripenem for injection)

DORIBAX is an intravenous (IV) antibiotic for hospital use, and belongs to a class of antibacterial drugs called carbapenems. Carbapenems are important antibiotics to treat serious - and often life-threatening - infections caused by a broad range of bacteria.

DORIBAX was approved in the U.S. in October 2007 for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI), including pyelonephritis, due to susceptible bacteria, and is marketed by Ortho-McNeil, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc. DORIBAX is also approved in the EU and Russia for cIAI, cUTI and NP, including VAP. Doripenem is licensed from Shionogi & Co., Ltd.

INDICATIONS

DORIBAX(TM) (doripenem for injection) is indicated as a single agent for the treatment of:

-- Compli
'/>"/>

SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Georgia Reproductive Specialists Participates in Largest-Ever In Vitro Fertilization Clinical Trial in the World
2. Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria
3. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
4. Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria
5. MatTeks EpiDerm In Vitro Tissues Headed for Validation in Europe
6. Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
7. Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival
8. New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias
9. Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza
10. Molnlycke Drives Home the Fight Against Staph and Other MRSA Infections
11. Mayo Clinic Study Finds FDA Warning Against Anti-Nausea Drug Droperidol Unnecessary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)...  Novastem, a leader in regenerative medicine, announces ... study for ischemic stroke at Clinica Santa Clarita. ... account for 87 percent of all stroke cases. ... study, entitled "Internal Research Protocol in Combination Therapy ... and Intrathecal Administration of Neural Stem Cells in ...
(Date:12/24/2014)... Kinex Pharmaceuticals announced today that the first ... Cancer Institute. KX2-361 (KX02), a dual src/pre-tubulin ... potent inhibitory activity against a broad panel of brain ... Temozolomide (T98G), the most widely used chemotherapy for the ... mouse model, KX2-361 consistently clears brain tumors after 4 ...
(Date:12/24/2014)... 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... proud to announce Jennifer Hagerman , Pharm.D., AE-C, ... take office as the president of the Michigan Pharmacists ... will take place Feb. 28, 2015, at the MPA ... the Renaissance Center in Detroit, Michigan ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... sick children with complex chronic illnesses can receive effective, less ... home," with easy access to a team of dedicated health ... likely to become seriously ill and need either hospitalization or ... at an enhanced medical home clinic at the University of ...
(Date:12/25/2014)... (HealthDay News) -- Among early stage breast cancer patients ... of one percent will eventually develop leukemia as a ... The finding comes from a review of more than ... and it suggests that the risk for developing treatment-related ... previously thought. "The frequency of bone marrow cancers ...
(Date:12/25/2014)... 25, 2014 Thousands of transvaginal mesh ... in a number of multidistrict litigations currently underway in ... Liebhard LLP reports. According to an Order issued on ... a Joint Status Conference in all of the proceedings ... been directed to submit a proposed agenda to the ...
(Date:12/25/2014)... North Carolina (PRWEB) December 25, 2014 ... North Carolina Retirement Community, recently showed their generous ... girls of the Catawba County Parenting Network- Grandparents ... the 10 children gathered around the largest Christmas ... to open presents purchased by residents of the ...
(Date:12/24/2014)... December 25, 2014 AlignLife of Wauwatosa ... to afford certain items. During the holiday season, AlignLife looks ... over 70 toys," says Dr. Sara Mahalko-Leonhardt, owner of AlignLife. ... such joy, knowing that we are able to give kids ... it not been for the generosity of our patients." , ...
Breaking Medicine News(10 mins):Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2
... consumer,employer and labor organizations today announced a ... health insurers on principles,to guide how health ... to consumers., The "Patient Charter for ... today creates a national set of principles,to ...
... Turns Assets from Retirement Plans Into Guaranteed Income for ... ... NEW YORK, April 1, 2008 AXA Equitable Life,Insurance Company, ... variable annuity -- Crossings(SM): My Lifetime,IRA(SM), designed specifically as a ...
... disease , , TUESDAY, April 1 (HealthDay News) -- The weight-loss ... buildup of arterial plaque that,s connected with carrying too much ... evidence that the drug actually slowed disease progression, although it ... in arteries. , Acomplia also showed a high rate ...
... drug discovery and the pharmaceutical industry currently underway will ... to a top researcher at the National Institutes of ... drug research and development. , According to ... Center (NCGC), both industry and academia welcome more cooperation ...
... 2008) A catheter-mounted device that acts like a ... heart valve is not only reducing the abnormal backflow ... atrium, it is helping to shrink the enlarged, overworked ... surgery. These are the one-year findings in a small ...
... A new study has found that an x-ray dye ... prevent renal injury during percutaneous coronary intervention (PCI) in ... it made no difference in the need for dialysis ... the Contrast Media and Nephrotoxicity Following Coronary Revascularization by ...
Cached Medicine News:Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 2Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 3Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 4Health News:Consumers, Health Care Purchasers, Physicians, and Health Insurers Announce Agreement on Principles to Guide Physician Performance Reporting 5Health News:AXA Equitable Unveils Crossings(SM): My Lifetime IRA(SM) 2Health News:AXA Equitable Unveils Crossings(SM): My Lifetime IRA(SM) 3Health News:AXA Equitable Unveils Crossings(SM): My Lifetime IRA(SM) 4Health News:AXA Equitable Unveils Crossings(SM): My Lifetime IRA(SM) 5Health News:AXA Equitable Unveils Crossings(SM): My Lifetime IRA(SM) 6Health News:AXA Equitable Unveils Crossings(SM): My Lifetime IRA(SM) 7Health News:Obesity Drug Shows Mixed Success Against Atherosclerosis 2Health News:Obesity Drug Shows Mixed Success Against Atherosclerosis 3Health News:Business of drug development on verge of great change 2Health News:Catheter repair of mitral valve improves heart size, symptoms 2Health News:Catheter repair of mitral valve improves heart size, symptoms 3Health News:Iso-osmolar X-ray dye falters in PCI study 2Health News:Iso-osmolar X-ray dye falters in PCI study 3
Batch Detection of Soluble Fibrin Monomer Complexes by the Hemagglutination Technique, 40 tests....
For use with catalog #0540....
Enzyme Immunoassay of D-Dimer by ELISA Method, 96 tests....
Lupus Anticoagulant-Sensitive APTT Reagent.Cephalin with particulate activator (silica), freeze-dried....
Medicine Products: