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New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy
Date:9/24/2008

nix(TM) the incidence of CNS side effects was low. (2,3,4)

Quality of life and depressive symptoms

The effect of Zebinix(TM) on quality of life was analysed using the Quality of Life Epilepsy Inventory-31 (QOLIE-31) scale. There was a statistically and clinically significant improvement from baseline during long-term open-label therapy, including:5

- 16 per cent mean relative improvement in overall quality of life

(p<0.0001).

- 51 per cent improvement in worry about seizures (p<0.0001)

- 41 per cent improvement in social function (p<0.001)

Improvement in depressive symptoms was also measured using the Montgomery Asberg Depression Rating Scale (MADRS). Zebinix(TM) demonstrated a significant improvement in depressive mood and symptoms from baseline (p<0.0001).(6)

Notes to Editors

About partial seizures and their treatment

Epilepsy is one of the most common neurological diseases, affecting almost 1 in 100 people.(8) Treatment of partial seizures, the most common type of epilepsy, presents a constant challenge - up to 58% of patients with partial seizures do not achieve seizure control with current antiepileptic drugs.(9)

Furthermore, adverse events, such as dizziness and somnolence, are highly prevalent with existing anti-epileptic agents and may affect as many as 97% of patients.(10) Hence, there is a need for new anti-epileptic agents that offer effective reduction in seizure frequency combined with a favourable safety profile.

Epilepsy is characterised by abnormal firing of impulses from nerve cells in the brain. In partial-onset epilepsy, these bursts of electrical activity are initially focused in specific areas of the brain, but may become more generalised; the symptoms vary according to the affected areas. Nerve impulses are triggered via voltage-gated sodium channels in the nerve cell membrane.

About Zebinix(TM)

Zebinix(TM) is a novel voltage-gated sodium chan
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