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New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias
Date:9/18/2007

CHICAGO, Sept. 18 /PRNewswire/ -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C., today announced that the investigational antibiotic doripenem was found to clinically cure 81% of patients with nosocomial pneumonia (NP), and 68% of patients with ventilator-associated pneumonia (VAP) in studies comparing doripenem to commonly used therapies.

These new data were presented in both oral and poster sessions at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

Doripenem belongs to a class of antibacterial agents called carbapenems, which are useful in treating serious life-threatening infections caused by Gram-negative* and Gram-positive** bacteria. Doripenem is licensed from Shionogi & Co., Ltd., which launched the product in Japan in September 2005.

Nosocomial pneumonia is acquired in either a hospital or other healthcare setting and typically manifests at least 48 hours after admission. Ventilator-associated pneumonia is a form of nosocomial pneumonia which occurs in people who are on mechanical ventilation because they cannot breathe on their own. Pseudomonas aeruginosa, a Gram-negative pathogen with increasing multi-drug resistance, is one of the leading causes of nosocomial infections, including nosocomial pneumonia.

According to the Centers for Disease Control and Prevention (CDC), two million Americans develop hospital-acquired infections each year, and approximately 90,000 die as a result. Approximately 70% of these infections are resistant to at least one antibiotic.

Data presented in an oral presentation demonstrated that 500 mg of doripenem administered intravenously every eight hours (500 mg IV q8h) was as effective and well tolerated as the standard combination of 4.5 g of piperacillin/tazobactam administered intravenously every six hours (4.5 g IV q6h) in patients with nosocomial pneumonia. In clinically evaluable patients, doripenem demonstrated an 81.3% clinical
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SOURCE Johnson & Johnson Pharmaceutical Research & Development,
L.L.C.
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