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New Data Show Ceftobiprole as Effective as Combination Therapy in Treating Patients with Diabetic Foot Infections
Date:10/8/2007

RARITAN, N.J., Oct. 8 /PRNewswire/ -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. today announced results from a Phase III trial that showed that investigational antibiotic ceftobiprole was found to clinically cure 86% of patients with diabetic foot infections -- including some infections that were caused by methicillin-resistant Staphylococcus aureus (MRSA).

These data were presented at the 45th annual meeting of the Infectious Disease Society of America (IDSA) in San Diego, California. Ceftobiprole is licensed from, and is being co-developed with, Basilea Pharmaceutica Ltd.

Staphylococcus aureus is the predominant Gram-positive+ bacteria associated with many infections, including complicated skin and skin structure infections (cSSSI) and is carried by approximately 25-30% of the U.S. population. During the last 30 years, MRSA has become more prevalent as a cause of complicated skin and skin structure infections, including diabetic foot infections, which are particularly challenging to treat. In 1974, MRSA accounted for 2% of all Staphylococcus infections in the U.S. In 2004, this figure had risen to 63%.

According to the American Diabetes Association (ADA), nearly 21 million Americans suffer from diabetes. Diabetic foot infections can develop in the skin, muscle, or bones of the foot as a result of nerve damage and poor circulation associated with diabetes. A recent ADA study approximates that as many as 9% of Americans with diabetes will develop a diabetic foot infection, and that those who do develop such an infection are 55.7 times more likely to require hospitalization and 154.5 times more at risk of amputation.

Ceftobiprole belongs to a class of antibacterial agents known as cephalosporins, which are used to treat serious infections caused by Gram- negative++ and Gram-positive+ bacteria. In clinically evaluable patients, 500mg of ceftobiprole administered intravenously every eight hours (500mg IV q8h) demonst
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SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
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