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New Data Show Ceftobiprole as Effective as Combination Therapy in Treating Patients With Complicated Skin Infections, Including MRSA
Date:9/18/2007

al, ceftobiprole alone was as effective as the combination therapy at eradicating methicillin-susceptible S. aureus (MSSA) (91% vs. 92%, respectively); MRSA (87% vs. 86%); S. pyogenes (90% vs. 100%); S. agalactiae (81% vs. 75%); E. coli (86% vs. 92%); P. aeruginosa (83% vs. 89%); and, Enterobacter spp., Klebsiella pneumoniae, and Proteus mirabilis (86% vs. 83%) from the site of infection.

Other data from two, pooled, Phase III, double-blind, randomized, multi- center global trials involving 817 patients with cSSSI examined the frequency and clinical outcome of patients infected with PVL-positive S. aureus. Patients were randomized to receive either 500 mg of ceftobiprole administered intravenously every eight or every 12 hours (500 mg IV q8h or q12h), 1 g of vancomycin administered intravenously every 12 hours, or a combination of 1 g of vancomycin administered intravenously every 12 hours (1 g IV q12h) plus 1 g of ceftazidime administered intravenously every eight hours (1 g IV q8h). Results showed that 38% of the S. aureus (n=310), 28% of MSSA (n=157/565), and 51% of MRSA (n=157/310) causing these skin infections were PVL-positive.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD) is part of Johnson & Johnson, the world's most broadly based producer of healthcare products. J&JPRD is headquartered in Raritan, NJ, and has facilities throughout Europe, the United States and Asia. J&JPRD is leveraging drug discovery and drug development in a variety of therapeutic areas to address unmet medical needs worldwide.

[This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the Company's expectations
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SOURCE Johnson & Johnson Pharmaceutical Research & Development,
L.L.C.
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