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New Data Reinforces Safety Profile of Abbott's Market-Leading XIENCE V(R) Drug Eluting Stent
Date:5/25/2010

PARIS, May 25 /PRNewswire-FirstCall/ -- Two late-breaking clinical trials presented today at the EuroPCR 2010 conference reinforced the outstanding clinical data supporting Abbott's market-leading XIENCE V® Everolimus Eluting Coronary Stent System. In the XIENCE V USA study of more than 5,000 real-world, complex patients, XIENCE V demonstrated a low rate of blood clots (stent thrombosis) at one year (0.84 percent per Academic Research Consortium [ARC] definition of definite/probable stent thrombosis). In a subset of approximately 1,800 less complex patients (referred to as "standard risk"), XIENCE V demonstrated a one-year stent thrombosis rate of 0.34 percent per ARC definition of definite/probable stent thrombosis.

"The low stent thrombosis rate demonstrated by XIENCE V is impressive given the complexity of the patient population included in the XIENCE V USA trial, and confirms that the stent thrombosis results seen with XIENCE V in earlier randomized clinical trials are consistent in real-world clinical practice," said James Hermiller, M.D., director of Cardiovascular Interventions, St. Vincent Hospital in Indianapolis, Ind., and principal investigator of the XIENCE V USA trial.

The XIENCE V USA study also showed that stent thrombosis rates remained low even when dual anti-platelet therapy (DAPT) was temporarily or permanently discontinued. In the overall XIENCE V USA population, patients who interrupted DAPT usage after six months showed a subsequent late stent thrombosis rate of zero percent. In the subset of standard risk patients, those who interrupted DAPT usage after 30 days also showed a subsequent late stent thrombosis rate of zero percent. DAPT compliance in the XIENCE V USA study was 79.4 percent at one year.  


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