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New Data Published in The Lancet Show GSK's ROTARIX(R) Offers Protection Against the Most Common Circulating Rotavirus Types
Date:11/23/2007

doses. If approved, the vaccine could be integrated into the current vaccine schedule at the two and four month immunization visits.

About ROTARIX(R)

The GSK rotavirus candidate vaccine is a live-attenuated oral rotavirus vaccine licensed in more than 100 countries around the world. The vaccine is designed to prevent rotavirus gastroenteritis by mimicking the protective effects of natural human rotavirus infection. Studies have shown that natural rotavirus infection provides significant protection from moderate to severe disease, regardless of rotavirus strain. In clinical trials conducted in support of US licensure, the most common solicited adverse reactions were fussiness, runny nose, fever, loss of appetite, and vomiting. Adverse reactions among recipients of ROTARIX and placebo occurred at similar rates.

About Rotavirus

Rotavirus infects virtually every child worldwide by age five and is the leading cause of severe acute gastroenteritis in infants and young children in the U.S. and worldwide. Severe diarrhea and dehydration occur primarily from as young as three months of age. In the U.S. each year, 2.7 million children younger than five years of age suffer from rotavirus disease, resulting in 410,000 clinic visits and up to 272,000 emergency room visits. In addition, between 55,000 and 70,000 children are hospitalized and 20-60 die each year. In the U.S., the rotavirus season begins in the southwest during November- December and spreads to the northeast by April-May.

GlaxoSmithKline: A Leader in Vaccines

GlaxoSmithKline, with U.S. operations in Philadelphia, PA, and Research Triangle Park, NC, is one of the world's leading research-based pharmaceutical and healthcare companies and is committed to improving the quality of human life by enabling people to do more, feel better and live longer.

GSK Biologicals (GSK Bio), one of the world's leading vaccine manufacturers, is headquartered in Rixensart, Belgium, where
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SOURCE GlaxoSmithKline
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