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New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy
Date:10/15/2007

the study was 69 percent for Lamictal XR and 62 percent for placebo. The most common adverse events in this study were headache (Lamictal XR, 17 percent vs. placebo, 15 percent) and dizziness (Lamictal XR, 18 percent vs. placebo, 5 percent). Non-serious rash was reported as an adverse event in two patients receiving Lamictal XR and in one patient receiving placebo. One of the two patients taking Lamictal XR withdrew prematurely from the study due to non- serious rash. No serious rashes were observed in either treatment group.

About Epilepsy

Epilepsy is defined by recurrent unprovoked seizures, or changes in sensation, awareness, or behavior brought about by electrical disturbances in the brain. The kind of seizure a person has depends on which part and how much of the brain is affected by the electrical disturbance that produces seizures. Generalized seizures are seizures that involve the entire brain from the outset. Partial seizures, which are the most common form of epilepsy, involve a restricted area of the brain. In approximately 70 percent of cases, the cause of epilepsy is unknown. According to the Epilepsy Foundation, more than 3 million Americans of all ages are living with epilepsy.

About Lamictal

Lamictal XR is an investigational therapy currently under review by the Food and Drug Administration. The immediate-release formulation of Lamictal is indicated 1) as adjunctive therapy for partial seizures, primary generalized tonic-clonic seizures, and the generalized seizures of Lennox-Gastaut syndrome in adults and pediatric patients as young as 2 years and 2) for conversion to monotherapy in adults with partial seizures taking carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single AED.

Safety and effectiveness of Lamictal have not been established 1) as initial monotherapy, 2) for conversion to monotherapy from AEDs other than carbamazepine, phenytoin, phenobarbital, primidone, or valproate, 3) for simul
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SOURCE GlaxoSmithKline
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