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New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy
Date:10/15/2007

Investigational Extended-Release Formulation Reduced Seizures in Patients

Who Were Inadequately Controlled

RESEARCH TRIANGLE PARK, N.C., Oct. 15 /PRNewswire-FirstCall/ -- New recently published data show that Lamictal(R)XR(TM) (lamotrigine) Extended- Release Tablets significantly reduced the frequency of partial seizures in inadequately controlled patients with epilepsy.

Lamictal XR is an extended-release formulation of Lamictal(R) (lamotrigine) currently in development as adjunctive therapy for patients with partial epilepsy with or without secondary generalization. Partial seizures, which are the most common form of epilepsy, involve a restricted area of the brain. Secondarily generalized seizures start out affecting only one side of the brain and evolve to affect both sides.

Results from this study, published in the October 16, 2007 edition of Neurology demonstrated that Lamictal XR reduced partial seizures by 46 percent over the entire 19-week treatment period compared to 24 percent with placebo. All patients enrolled in the study were inadequately controlled on one or two antiepileptic drugs. The study also showed that 42 percent of patients treated with Lamictal XR achieved at least a 50 percent reduction in seizure frequency compared to 24 percent of patients receiving placebo, a reduction that was reached by some patients as early as Day 18 of the study and was sustained over the entire 19-week treatment period.

"Many patients require multiple doses of one or more medications to control their epilepsy, which makes taking their medicines correctly and at the right times even more challenging," said Dean Naritoku, M.D., Professor of Neurology and Pharmacology, Southern Illinois University, Springfield, IL. "These data are important as they show investigational Lamictal XR taken once- daily significantly reduced seizure frequency among previously uncontrolled patients.

About This Study

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SOURCE GlaxoSmithKline
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