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New Data On Xeomin® (IncobotulinumtoxinA) To Be Presented At The 15th International Congress Of Parkinson's Disease And Movement Disorders (MDS)
Date:6/8/2011

"These findings are supportive of a flexible dosing schedule for XEOMIN, which can be determined according to individual needs," said Matthew Brodsky, M.D., Director of the Neurotoxin Injection Program and Movement Disorders Program at Oregon Health & Science University, Portland, Ore. "Cervical dystonia and blepharospasm are variable chronic conditions that affect each patient differently, so it's important that physicians work with their patients to determine appropriate treatment regimens and dosing schedules on a case by case basis."

In both studies, there were no significant differences in the overall occurrence of treatment-emergent-adverse-events among groups (using chi-square test).

About The Studies

Patients with CD or blepharospasm who completed a placebo-controlled, double-blind study (up to 20 weeks) evaluating the safety and efficacy of XEOMIN, could enter an open label extension (OLEX) phase for blepharospasm treatment or an extension phase (EP) for CD treatment.

Blepharospasm patients (n=102) who entered the OLEX phase were treated with XEOMIN (up to 50 Units) for up to 69 weeks. Repeated injection intervals were chosen at the discretion of the physician and patient, based on the Jankovic Rating Scale (JRS) Severity subscore. In the subgroup analysis the JRS Sumscore (Severity and Frequency Subscores) was the primary outcome measure and all JRS Sumscores were significantly improved after each injection (p<0.001) in each group (using paired t-test).

Cervical dystonia patients (n=214) who entered the EP were treated with XEOMIN (111 in 240 Units group; 103 in 120 Units group) for up to 68 weeks. Inter-injection intervals were chosen at the discretion of the physician and patient, based on Toronto Western Spasmodic Rating Scale (TWSTRS) Total score. In the subgroup analysis the primary efficacy outcome measure was TWSTRS Total scores, which were significantly improved after each injection (p<0.0
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SOURCE Merz Pharmaceuticals
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