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New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens
Date:6/1/2008

TYKERB Demonstrates Activity in Combination with Other Targeted Therapies

and as Monotherapy Across A Range of Breast Cancer Settings - First Phase II data investigating the dual inhibition of HER2 and VEGF pathways with two oral, small molecule tyrosine-kinase inhibitors (TYKERB and pazopanib) demonstrates activity in first-line HER2 (ErbB2) positive

breast cancer(1)

- Phase II results combining TYKERB and AVASTIN(R) (bevacizumab), a monoclonal antibody, shows activity in recurrent metastatic HER2-positive

breast cancer(2)

- Final results from the largest prospective trial evaluating TYKERB monotherapy as a treatment for relapsed inflammatory breast cancer (IBC) demonstrates activity in this highly aggressive and difficult to treat

disease(3)

LONDON, and PHILADELPHIA, June 1 /PRNewswire-FirstCall/ -- GlaxoSmithKline today announced the results of three studies evaluating TYKERB -- an oral, small molecule inhibitor of HER2 -- in various breast cancer settings, either in combination with other targeted therapies or as a monotherapy. Use of TYKERB in these settings is investigational. Results from these studies are being presented during the annual American Society of Clinical Oncology (ASCO) meeting in Chicago, May 30 - June 3, 2008.

Multiple cellular pathways influence the growth and metastatic potential of tumors, which is thought to be related to the ability of cancer cells to develop primary or acquired resistance.(4) It is believed that targeted inhibition of several tumor cell signaling pathways may be more effective than inhibition of a single pathway alone.(4)

"Targeted therapies, either used in combination or as a single agent, are the future of cancer treatment and may have the potential to treat patients more effectively," said Dr. Paolo Paoletti, Senior Vice President of the Oncology Medicine Developm
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SOURCE GlaxoSmithKline
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