Navigation Links
New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens
Date:6/1/2008

TYKERB Demonstrates Activity in Combination with Other Targeted Therapies

and as Monotherapy Across A Range of Breast Cancer Settings - First Phase II data investigating the dual inhibition of HER2 and VEGF pathways with two oral, small molecule tyrosine-kinase inhibitors (TYKERB and pazopanib) demonstrates activity in first-line HER2 (ErbB2) positive

breast cancer(1)

- Phase II results combining TYKERB and AVASTIN(R) (bevacizumab), a monoclonal antibody, shows activity in recurrent metastatic HER2-positive

breast cancer(2)

- Final results from the largest prospective trial evaluating TYKERB monotherapy as a treatment for relapsed inflammatory breast cancer (IBC) demonstrates activity in this highly aggressive and difficult to treat

disease(3)

LONDON, and PHILADELPHIA, June 1 /PRNewswire-FirstCall/ -- GlaxoSmithKline today announced the results of three studies evaluating TYKERB -- an oral, small molecule inhibitor of HER2 -- in various breast cancer settings, either in combination with other targeted therapies or as a monotherapy. Use of TYKERB in these settings is investigational. Results from these studies are being presented during the annual American Society of Clinical Oncology (ASCO) meeting in Chicago, May 30 - June 3, 2008.

Multiple cellular pathways influence the growth and metastatic potential of tumors, which is thought to be related to the ability of cancer cells to develop primary or acquired resistance.(4) It is believed that targeted inhibition of several tumor cell signaling pathways may be more effective than inhibition of a single pathway alone.(4)

"Targeted therapies, either used in combination or as a single agent, are the future of cancer treatment and may have the potential to treat patients more effectively," said Dr. Paolo Paoletti, Senior Vice President of the Oncology Medicine Developm
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. RediClinic Offers Affordable New Plan Clinically Shown to Double a Persons Chance to Stop Smoking
2. Spine Institute of Louisiana Offers Cervical Spine Motion Preservation as an Alternative to Fusion Surgery
3. CVS/pharmacy Offers Flu Vaccinations in Over 4,000 Stores
4. Spit for the Cure Offers Unique Opportunity for Women to Participate in Breast Cancer Research
5. Concentra Offers Flu Vaccines to Keep America Working
6. New Report by Pediatricians Finds Gaps in Preparing to Protect Kids From Pandemic Flu, Offers Recommendations
7. UPDATE: New Report by Pediatricians Finds Gaps in Preparing to Protect Kids From Pandemic Flu, Offers Recommendations
8. New UNAIDS Report Offers Encouraging News, But Most HIV-Positive Mothers Still Not Getting the Care & Treatment They Need
9. New Data Published in The Lancet Show GSKs ROTARIX(R) Offers Protection Against the Most Common Circulating Rotavirus Types
10. Researcher Investigates Disparities in Doctor-Patient Information Exchange During Clinical Trial Offers
11. New Report Offers Hope for Closing Health Gap for African Americans, With Nearly 700 Medicines in Pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... , Sept. 2, 2014 /PRNewswire-iReach/ -- The ... by universal healthcare coverage and good access to ... population and its associated disease burden, well-defined regulatory ... introduction of a new manufacturing policy will drive ... However, a focus on generic substitution and price ...
(Date:9/2/2014)... , Sept. 2, 2014  Cyberonics, Inc. ... from the ANTHEM-HF clinical study.  Results of the ... during a major European cardiology congress and concurrently ... show Autonomic Regulation Therapy (ART) in patients ... impaired heart function is safe, improves the heart,s ...
(Date:9/2/2014)... , Sept. 2, 2014  Based on ... treatment device market, Frost & Sullivan recognizes Novian ... & Sullivan Award for Technology Innovation Leadership. Novian ... fibroadenoma and malignant tumors with its proprietary technology, ... is a reliable, accurate, and easy-to-control ultrasound-guided thermo ...
Breaking Medicine Technology:Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 2Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 3Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 4Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 5ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 2ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 3ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 4ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 5Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 2Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 3Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 4Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 5
... , CINCINNATI , June 21 ... to its HARMONIC® line of surgical devices, the HARMONIC ... designed to extend the reach of surgeons for minimally ... (or 9cm) than the standard length HARMONIC ACE® device. ...
... today announced that six-month clinical follow-up data show the safety and ... (Sequent Please®, B.Braun) followed by implantation of the company,s Genous Bio-engineered ... , , ... single center, all-comers POTENT ( P aclitaxel-eluting ball O on and ...
Cached Medicine Technology:Ethicon Endo-Surgery Introduces HARMONIC ACE® 45 cm Curved Shears at ASMBS 2Ethicon Endo-Surgery Introduces HARMONIC ACE® 45 cm Curved Shears at ASMBS 3Data Show OrbusNeich's Genous™ Bio-engineered R stent™ is Safe and Effective in Combination with Drug-Eluting Balloon 2Data Show OrbusNeich's Genous™ Bio-engineered R stent™ is Safe and Effective in Combination with Drug-Eluting Balloon 3
(Date:9/2/2014)... The use of Xarelto (known generically ... at a rapid pace, even as Xarelto lawsuits ... the U.S., Bernstein Liebhard LLP reports. According to a ... a year of its 2011 launch, patients were just ... blood thinner that has been in use for several ...
(Date:9/2/2014)... in California, the percentage undergoing a double mastectomy increased ... not associated with a lower risk of death than ... the September 3 issue of JAMA . The ... one breast was associated with a higher risk of ... , Randomized trials have demonstrated similar survival for patients ...
(Date:9/2/2014)... September 02, 2014 The Dream2Walk Foundation along ... on Sept. 14th, 2014 during Spinal Cord Injury Awareness Month ... Lynn England, and Chuck Ligon. Linear Automotive will be there ... show. , Doors open at 2pm. The car show is ... one free pass to the concert. There will be trophies ...
(Date:9/2/2014)... -- Melatonin supplements did not reduce delirium in seniors ... found. Many older hospital patients experience the sudden, ... their normal sleep-wake cycle. A lack of the hormone ... but there has been little research into whether melatonin ... 378 patients, average age 84, who had hip fracture ...
(Date:9/2/2014)... LOS ANGELES (Sept. 2, 2014) Measuring the levels of ... suffer a sudden cardiac arrest, a heart rhythm disorder that ... new study, published online by the peer-reviewed journal Heart ... male sex hormone, were found in men who had a ... sex hormone, were strongly associated with greater chances of having ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 2Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 3Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 4Health News:Increase seen in use of double mastectomy 2Health News:Increase seen in use of double mastectomy 3Health News:Gas Monkey Hosts Concert in Dallas Benefiting Dream2Walk Foundation with Linear Automotive 2Health News:Study links sex hormone levels in the blood to risk of sudden cardiac arrest 2
... will develop one or more chronic health problems later in ... a study released Tuesday suggested. ,Dutch researchers ... cancer survivors found that 75 percent went on to develop ... reached their mid 20s, or early 30s at the latest. ...
... increased risk of jaw or facial bone deterioration or ... lesions, elevated levels of calcium in the blood, or ... found an association between the use of intravenous bisphosphonates ... condition in which poor blood supply to the area ...
... set to turn into a "no-smoking zone" by mid-July this year. ... be fully enforced from July 15 and will cover markets, restaurants ... users annually in the country. , ,The establishment says ... utilities will be allowed to set up a separate area for ...
... (IANS) Nearly 100 people have been bitten and injured by ... anti-rabies vaccines in the government hospitals to treat the patients. ... has attacked and injured villagers - including women and children ... of the district, about 200 km from here. ...
... program cuts diabetes risk and is more effective at ... overweight children. ,A family-based weight management ... was more successful at plummeting weight, body fat, BMI ... ,Mary Savoye-Desanti, research associate in Yale's Department of ...
... substantial progress in curbing the spread of polio with just 82 ... to 676 last year, says WHO. ,Of the ... Uttar Pradesh and 17 from Bihar, it says. ... with 585 for the same period in 2006,' said a WHO ...
Cached Medicine News:Health News:Childhood Cancer can Lead to Chronic Health Problems Later in Life: Study 2Health News:Bisphosphonate Increases the Risk of Jaw Bone Deterioration 2Health News:Chandigarh Set to Be No-smoking Zone from July 15 2Health News:Bright Bodies Weight Program Lowers Diabetes Risk, BMI in Obese Kids 2Health News:India Records Substantial Decline in Polio Cases 2
Female Compression VEST w/sleeves...
Male Support Brief...
Ideal for lower abdominal procedures. Comes with a left side separating zipper....
Arm Compression Garment...
Medicine Products: