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New Data From Head-to-Head Study Confirms Once-Daily Levemir(R) is as Effective as Glargine over a 24-Hour Period in Subjects with Type 2 Diabetes
Date:6/8/2008

ir to glargine in a single daily dose over a 24-hour period using continual glucose monitoring system (CGMS), showing that Levemir had a comparable blood glucose response to insulin glargine.

Patients with type 2 diabetes using basal insulin without bolus insulin (N=35) were randomized to receive a single daily injection of Levemir or glargine at 8 p.m. for one week in order to achieve steady state levels of insulin in the body. At the end of the week, subjects were switched to the other insulin.

Both insulins were titrated to achieve blood glucose targets during a pre-specified basal period (12 p.m. to 6 a.m.). No food was eaten between 6 p.m. to ~7 a.m. in order to obtain accurate basal readings.

Once basal blood glucose targets were achieved, CGMS readings for the last 24-hour period were recorded and mean values were compared between treatments using a single-tailed, paired t-test.

Levemir Shows Similar Daily Average Consumption versus Glargine

A retrospective analysis of insulin-naive patients with type 2 diabetes enrolled in a major US health plan compared daily average consumption (DACON) of and glycemic control with the insulins Levemir and glargine, along with associated medical costs. Results showed that there was no difference in HbA1c values between Levemir and insulin glargine cohorts, and no significant difference in DACON.

Researchers monitored insulin-naive patients with type 2 diabetes age 18 and older who were enrolled in a large US health plan. Using propensity score matching, it was found that 48 patients started insulin detemir therapy, and 258 started insulin glargine therapy, over a six-month period. Besides reducing selection bias due to observed baseline characteristics, propensity score matching also ensures that patients in insulin detemir and insulin glargine cohorts have similar distribution of the baseline characteristics. This ensured that patients included in the insulin detemir and insulin gl
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SOURCE Novo Nordisk
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