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New Data From Head-to-Head Study Confirms Once-Daily Levemir(R) is as Effective as Glargine over a 24-Hour Period in Subjects with Type 2 Diabetes
Date:6/8/2008

SAN FRANCISCO, June 8 /PRNewswire-FirstCall/ -- A head-to-head study announced today at the American Diabetes Association (ADA) meeting demonstrated that Levemir(R) (insulin detemir [rDNA origin] injection) can be used once-daily and had a comparable blood glucose response to insulin glargine over a 24-hour period in patients with type 2 diabetes.

"Our study reinforces that once-daily Levemir has a similar 24-hour action profile as once-daily glargine," said Professor Allen B. King, Diabetes Care Center, Salinas, CA, whose research compared 24-hour blood glucose response of Levemir and glargine.

A retrospective study using recent data from a large US health plan database showed that in addition to providing similar blood glucose response as glargine, Levemir had no significant difference vs. glargine in daily average consumption and diabetes related pharmacy costs.

Novo Nordisk Announces the Decision to Conduct the First and Only Safety

and Efficacy Study to Compare Once-Daily Levemir(R) vs. Once-Daily

Glargine

Novo Nordisk also announced today the first and only full scale study of once-daily Levemir versus a single daily dose of glargine to generate the first robust comparative data set of the two treatments.

"By finally establishing the efficacy profiles of these drugs in a direct and fair comparison, we will help physicians choose the best possible treatment for their patients," said Mads Krogsgaard Thomsen, Chief Science Officer. "In clinical trials with patients with type 2 diabetes, once-daily Levemir has repeatedly shown 24-hour glycemic control, improved HbA1c control and a low incidence of hypos, with the addition of a weight benefit. For people with diabetes, once-daily Levemir may offer an attractive package."

Levemir Shows Comparable Blood Glucose Response versus Glargine

The head-to-head, randomized, double-blind crossover study compared the blood glucose response of once-daily Levem
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SOURCE Novo Nordisk
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