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New Data Examines the Effect of Adding a Statin to Optimized Treatment for Patients with Advanced Heart Failure
Date:11/5/2007

gression of atherosclerosis to prevent one of its worst consequences, heart failure."

"The CORONA study was a novel and challenging study and demonstrates our commitment to advancing medical knowledge by investigating the effects of CRESTOR in challenging patient populations with unmet medical need. The CORONA study included patients with advanced heart failure on optimal treatment who were not candidates for statin therapy in the view of the investigators and which sought to answer the question of whether or not statins provide additional benefit or might even be harmful in this population. As a result of this study, AstraZeneca has provided new scientific information to help answer these important questions", said Elisabeth Bjork, Global Medical Science Director for CRESTOR.

CORONA (COntrolled ROsuvastatin MultiNAtional Study in Heart Failure) was a long-term, randomized, placebo-controlled study of more than 5,000 patients with chronic, symptomatic, systolic heart failure (NYHA II-IV) of ischemic origin, whom investigators felt did not need lipid-lowering therapy. The study was designed to evaluate the effects of adding CRESTOR 10 mg to optimized treatment for heart failure on cardiovascular mortality and morbidity and overall survival.

CRESTOR 10 mg was well tolerated in over 2,500 patients during the study, with a safety profile similar to placebo. The frequency and type of adverse events were comparable in all treatment groups throughout the study. CORONA was conducted in 21 countries.

CORONA is a part of AstraZeneca's extensive GALAXY clinical trials program, designed to address important unanswered questions in statin research. Currently, more than 69,000 patients have been recruited from 55 countries worldwide to participate in the GALAXY Program.

CRESTOR has now received regulatory approvals in over 90 countries. Over 11 million patients have been prescribed CRESTOR worldwide. Data from clinical trials and real world use shows
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SOURCE AstraZeneca
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