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New Data Demonstrates Victoza® (liraglutide [rDNA] injection) Provided Superior and Sustained Blood Sugar Control and Weight Reduction Compared to Januvia® (sitagliptin) at One Year
Date:6/28/2010

#174; and Januvia® were well tolerated. Nausea initially occurred at higher rates with Victoza® 1.2 mg (21%) and 1.8 mg (27%) than Januvia® (5%). However, nausea with Victoza® was transient – most episodes occurred early with few withdrawals; by later weeks, the prevalence of nausea was similar to that of Januvia® with <2% reporting nausea in weeks 27-52.

Incretin-based diabetes treatments

Victoza® and Januvia® are both incretin-based diabetes therapies.  Victoza® is the first once-daily human GLP-1 analog that mimics the activity of endogenous, GLP-1, while Januvia®, a DPP-4 inhibitor, blocks the enzyme responsible for the breakdown of GLP-1 and other substances.

Consensus statements from the ADA and the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists, and the American College of Endocrinology recognize GLP-1 analogs as an effective add-on treatment for patients who are not responding to metformin and lifestyle changes alone.

Indications and Usage

Victoza® is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes when used with a diet and exercise program.

Victoza® is not recommended as the first medication to treat diabetes.  Victoza® is not insulin and has not been studied in combination with insulin.  Victoza® is not for people with type 1 diabetes or people with diabetic ketoacidosis.  It is not known if Victoza® is safe and effective in children.  Victoza® is not
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