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New Data Demonstrates Victoza® (liraglutide [rDNA] injection) Provided Superior and Sustained Blood Sugar Control and Weight Reduction Compared to Januvia® (sitagliptin) at One Year
Date:6/28/2010

anslational Medicine Unit, University of Vermont College of Medicine, Burlington.  "Although Victoza® is not indicated for the management of obesity, the study showed that Victoza® provided greater weight loss than Januvia®, which is a benefit for those patients struggling to maintain a healthy weight."

In addition, significantly more patients treated with Victoza® achieved the ADA recommended A1c target of <7.0%.  Nearly twice as many study participants on Victoza® reached the ADA goal compared to the Januvia® group (50% and 63% in the 1.2mg and 1.8mg Victoza® groups versus 27% in the Januvia® group).

About the study

This study extension compared the safety and efficacy of the two recommended doses of once-daily Victoza® (1.2 mg and 1.8 mg) with once-daily Januvia® (100mg), all added to metformin.  After the initial 26-week randomized, open-label trial, 497 patients were enrolled in this 26-week extension.  The trial was conducted in Europe and North America in people with type 2 diabetes who were not adequately controlled on metformin alone.

Secondary endpoints included the Diabetes Treatment Satisfaction Questionnaire (DTSQ), a validated measure used in many diabetes trials to measure the change in treatment satisfaction.  Improvement in overall treatment satisfaction was significantly greater with Victoza® 1.8 mg than Januvia®.  No overall differences in the perceived convenience of treatment (oral versus injection) were reported.

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SOURCE Novo Nordisk
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