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New Data Demonstrates 5-FU Personalized Chemotherapy Management (PCM(R)) Assay Provides Similar Performance to More Complicated Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
Date:6/23/2008

a levels were evaluated using the 5-FU PCM assay and cross- analyzed using LC-MS/MS cross-reactivity, precision, and stability to ensure accuracy. Researchers found that the PCM assay was precise and analytical results correlated well with those obtained from the validated HPLC method.

A recent study demonstrated that monitoring patients' 5-FU blood plasma levels and adjusting chemotherapy doses to achieve optimal levels of 5-FU can improve response rates and minimize toxicity when compared to standard-of-care dosing based on height and weight (known as body surface area or BSA). The May issue of the Journal of Clinical Oncology (JCO) featured results of a Phase III randomized study of colorectal cancer patients who were dosed with 5-FU based on the current standard, BSA compared with patients who had doses personalized according to 5-FU blood plasma levels. The study concluded that only 25 percent of patients were in target range, while 17 percent were found to be over-dosed and 58 percent of patients were found to be under-dosed. Additionally, this study demonstrated that after 5-FU doses was adjusted to achieve appropriate plasma levels, patients experienced improved response rates and nearly doubled overall survival, in addition to significantly lower toxicity.(ii)

About Personalized Medicine

Personalized medicine denotes treatments tailored individually for patients. Recognizing that patients respond differently to treatments, it is only recently that scientific tools have become available to enable identification of individual patient or disease differences at the molecular or genetic level. These tools enable physicians to formulate individualized treatment plans more effectively. For example, knowledge of genetic variations can now help physicians optimize breast cancer therapy or better manage dosing of blood thinning drugs.

About Colorectal Cancer

Colorectal cancer is a worldwide public health problem, with more than 940,
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SOURCE Saladax Biomedical
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