Navigation Links
New Data Demonstrates 5-FU Personalized Chemotherapy Management (PCM(R)) Assay Provides Similar Performance to More Complicated Liquid Chromatography-Mass Spectrometry (LC-MS/MS)
Date:6/23/2008

a levels were evaluated using the 5-FU PCM assay and cross- analyzed using LC-MS/MS cross-reactivity, precision, and stability to ensure accuracy. Researchers found that the PCM assay was precise and analytical results correlated well with those obtained from the validated HPLC method.

A recent study demonstrated that monitoring patients' 5-FU blood plasma levels and adjusting chemotherapy doses to achieve optimal levels of 5-FU can improve response rates and minimize toxicity when compared to standard-of-care dosing based on height and weight (known as body surface area or BSA). The May issue of the Journal of Clinical Oncology (JCO) featured results of a Phase III randomized study of colorectal cancer patients who were dosed with 5-FU based on the current standard, BSA compared with patients who had doses personalized according to 5-FU blood plasma levels. The study concluded that only 25 percent of patients were in target range, while 17 percent were found to be over-dosed and 58 percent of patients were found to be under-dosed. Additionally, this study demonstrated that after 5-FU doses was adjusted to achieve appropriate plasma levels, patients experienced improved response rates and nearly doubled overall survival, in addition to significantly lower toxicity.(ii)

About Personalized Medicine

Personalized medicine denotes treatments tailored individually for patients. Recognizing that patients respond differently to treatments, it is only recently that scientific tools have become available to enable identification of individual patient or disease differences at the molecular or genetic level. These tools enable physicians to formulate individualized treatment plans more effectively. For example, knowledge of genetic variations can now help physicians optimize breast cancer therapy or better manage dosing of blood thinning drugs.

About Colorectal Cancer

Colorectal cancer is a worldwide public health problem, with more than 940,
'/>"/>

SOURCE Saladax Biomedical
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease
2. Phase 1/2 Trial of Motexafin Gadolinium Plus Antibody Targeted Radiation Therapy Demonstrates High Complete Response Rate in Patients With Non-Hodgkins Lymphoma
3. Micromets BiTE Antibody Blinatumomab (MT103/MEDI-538) Demonstrates Durable Responses in Patients with Relapsed Non-Hodgkins Lymphoma
4. Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles
5. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
6. Phase I/II Study of Targeted Gene Delivery In Vivo - Intravenous Infusions of REXIN-G - Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma (ASCO 2008)
7. Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration
8. Tioga Pharmaceuticals Asimadoline Demonstrates Positive Results in a Phase 2b Clinical Trial for the Treatment of Irritable Bowel Syndrome
9. New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients
10. Study Demonstrates Lexapro(R) Significantly Improves Depression Symptoms in Adolescents
11. Clinical Data Demonstrates 5-Year Efficacy and Safety of Aquamid(R) in Facial Augmentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014   Ventana Medical Systems, Inc.  (Ventana), ... has entered into an agreement with Merck KGaA, Darmstadt, ... Serono in the United States ... Merck KGaA,s biopharmaceutical division on the development and commercialization ... using Ventana,s proprietary diagnostic assays. In alignment with Merck ...
(Date:7/10/2014)... , July 10, 2014 Decision Resources Group ... of the U.S. Food and Drug Administration,s (FDA) approval ... binder Velphoro, which was approved by the FDA in ... kidney disease (CKD) patients on dialysis. Other ... Nephrology (US) Q2 2014 : ...
(Date:1/15/2014)...  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the ... Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... in order to treat dental impairments, for tooth restoration ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
(Date:7/13/2014)... Recently, MyDressCity.com, one of the most popular ... has released its new range of elegant Quinceanera ... available at discounted prices. Worldwide clients can enjoy this ... the company’s online shop, there are plenty of beautiful ... with great materials. MyDressCity.com’s hot items are prom gowns, ...
(Date:7/13/2014)... A noninvasive optical imaging device developed at ... later occur in the brain and are a ... results from investigators conducting a clinical trial in ... July 15 in an oral presentation at the ... They also were invited by conference organizers to ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Wright & ... trial has been scheduled in July of 2015, in ... Lipitor lawsuits are in the discovery process in ... M. Gergel is presiding over the multidistrict litigation (MDL). ... on behalf of individuals who allege that they took ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 ECS ... who commented, “As a parent of a special needs ... need in the Seattle community for contemporary special education ... an important alternative to students and families in the ... practices and environment for special education. We welcome the ...
(Date:7/13/2014)... 13, 2014 According to The Peripheral ... a comprehensive program that teaches people how to deal ... without medications. This program also provides people with ... peripheral neuropathy , including numbness, prickling, burning, and intense ... that this home treatment program can help people eliminate ...
Breaking Medicine News(10 mins):Health News:Cheap Elegant Quinceanera Dresses Unveiled by MyDressCity.com 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 4Health News:New Private School, Emerald City School, Founded in Downtown Seattle Now Accepting 1st to 6th Grade Students Who Learn Differently 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 3
... do minor behavior problems and experiences early in life ... group of researchers has found that the answer may ... experiences lead to behaviors and new experiences that lead ... behavior. , The researchers found that children who had ...
... revenue exceeds $10 billion, COVINGTON, Ky. and ... ASH ) today completed its acquisition of Hercules,Incorporated, ... the world,s most essential needs and industries. Each ... $18.60 in cash and 0.093 of a,share of ...
... ... Business Assets, WAYNE, Pa., Nov. 13 Escalon Medical Corp.,(Nasdaq: ... ended,September 30, 2008., For the first quarter of fiscal 2009, ... fiscal 2007. This,included product revenue of $8,669,000 for the first quarter ...
... a leading,international manufacturer, marketer, and supplier of protective ... financial,results for the third quarter of 2008., ... were $265.2 million, an,increase of 8.2% over net ... of,2007. Excluding the impact of favorable foreign currency ...
... Inc. (Nasdaq: AMLN ) will be presenting at ... Wednesday, November,19, 2008 at 8:30 a.m. ET. Daniel M. ... be providing a corporate overview., The live presentation ... made,available following the event. The Web cast and recording ...
... N.J., Nov. 13 Pharmos Corporation,(Nasdaq: PARS ) ... Market ("Nasdaq") on November 11, 2008 that the Company ... requires the,Company to have a minimum of $2,500,000 in ... $500,000 of net income,from continuing operations for the most ...
Cached Medicine News:Health News:Cascading effect of even minor early problems may explain serious teen violence 2Health News:Ashland Completes Acquisition of Hercules 2Health News:Ashland Completes Acquisition of Hercules 3Health News:Ashland Completes Acquisition of Hercules 4Health News:Ashland Completes Acquisition of Hercules 5Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 2Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 3Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 4Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 5Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 6Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 7Health News:Escalon(R) Reports First Quarter Fiscal 2009 Results 8Health News:Pregis Announces Third Quarter 2008 Financial Results 2Health News:Pregis Announces Third Quarter 2008 Financial Results 3Health News:Pregis Announces Third Quarter 2008 Financial Results 4Health News:Pregis Announces Third Quarter 2008 Financial Results 5Health News:Pregis Announces Third Quarter 2008 Financial Results 6Health News:Pregis Announces Third Quarter 2008 Financial Results 7Health News:Pregis Announces Third Quarter 2008 Financial Results 8Health News:Pregis Announces Third Quarter 2008 Financial Results 9Health News:Pregis Announces Third Quarter 2008 Financial Results 10Health News:Pregis Announces Third Quarter 2008 Financial Results 11Health News:Pregis Announces Third Quarter 2008 Financial Results 12Health News:Pharmos Corporation Announces Receipt of Nasdaq Noncompliance Letter 2
... Capture vital signs faster, easier, and ... LXi, the latest innovation in multi-parameter ... Spot LXi, you get more parameters ... flexibility to customize it to meet ...
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Medicine Products: