New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Can... (al Centerand an advisor to Peregrine. Dr...)

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New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models

Date:11/13/2007

al Center, and an advisor to Peregrine. Dr. Brekken's study treated tumor-bearing animals with R84, Avastin, or a placebo in an orthotopic model of breast cancer. Treatment with R84 reduced the growth of well-established breast tumors by 55%, equivalent to the reduction achieved with Avastin. The researchers also demonstrated that R84 and Avastin were equally effective at controlling tumor growth in a preclinical model of sarcoma. In every preclinical tumor model evaluated thus far, the anti-tumor activity of R84 has been comparable to that of Avastin.

"These encouraging findings build on positive preclinical data we presented at the 2007 AACR meeting showing that Peregrine's selective anti-VEGF mouse antibody 2C3 and its fully human counterpart R3 demonstrated potent anti-cancer efficacy equivalent to Avastin in a model of pancreatic cancer," said Steven W. King, president and CEO of Peregrine. "We are delighted that R84 is generating similar, and potentially superior, results in preclinical cancer models. As a result of these positive developments, we are initiating additional preclinical studies to advance R84 as our next potential clinical candidate."

The study results also showed that tumor-associated macrophages, immune system cells found in tumors, are reduced after R84 therapy. Tumor-associated macrophages are often associated with poor prognosis as these cells are linked to increased angiogenesis and metastasis. In addition, the study data showed that when given for a prolonged period, R84 decreased microvessel density and expression of VEGFR2, demonstrating that the antibody is acting to reduce VEGF-induced angiogenesis in tumor tissue.

Dr. Brekken commented, "VEGF binding to VEGFR2 on blood vessels is a primary driver in promoting the development and maintenance of the blood vessels needed by tumors to survive and grow. These new studies further tested the hypothesis that selectively inhibiting VEGFR2 is an equally effective anti-tumor s
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New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Can...(al Centerand an advisor to Peregrine. Dr...),Health