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New Data Analyses on CONCERTA® Pediatric Treatment Include Insight on Handwriting Performance and Attention in ADHD
Date:10/29/2010

en they received placebo. Results showed patients had better handwriting performance on the days when they took CONCERTA® than on the days they took placebo.

Handwriting was assessed using the Test of Handwriting Skills-Revised (THS-R).  The THS-R is a standardized assessment designed to evaluate neurosensory integration shown in print and cursive writing. In a review of previously published studies, children with ADHD scored significantly lower than children without ADHD using this measure.(1) In the CONCERTA® sub-analysis presented today, the mean THS-R standard scores showed patients scored 91.46 on the day they took CONCERTA® versus 87.03 on the day they took placebo (p<0.0001).

In a separate sub-analysis of data (Poster 5.27) from the pooled classroom studies, CONCERTA® was compared to placebo using a skill-adjusted math test that measures attention in ADHD, known as the PERMP (Permanent Product Measure of Performance).

In this analysis, all 139 patients ages 9 to 12 had a confirmed diagnosis of ADHD, and 15 patients also had a co-morbid math-based learning disability (LD). The PERMP provided patients a series of math problems during the laboratory school day. The patients' performance on problems attempted and problems correctly answered was used to evaluate the effect of CONCERTA® on attention and focus.

Results of this sub-analysis showed patients with a math LD had higher mean PERMP scores for both the number of math problems attempted (93.8 vs. 67.2, respectively; p<0.01) as well as the number of math problems answered correctly (87.8 vs. 63.0, respectively; p<0.01) following treatment with CONCERTA® compared to placebo. Similarly, patients with no math LD also had higher mean PERMP scores in both measures after treatment with CONCERTA® compared to placebo (114.2 vs. 81.6, respectively; p<0.0001; 109.9 vs. 76.8, respectively; p<0.0001).

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SOURCE McNeil Pediatrics(TM)
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