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New Data: Cholesterol Management Analysis of Upsher-Smith's Slo-Niacin(R) Tablets in Combination with Lipitor(R)
Date:11/16/2009

ternate drug was then added in the next three month segment. Lipid profiles and liver enzymes were measured monthly. Additionally, a questionnaire regarding flushing was completed at each visit. Thirty-six participants finished the study.1

Monotherapy with Slo-Niacin® decreased median triglyceride levels 15 percent, mean LDL 12 percent and increased HDL 8 percent. Lipitor decreased median triglyceride levels 26 percent, mean LDL 36 percent and increased HDL 6 percent. Combined therapy decreased median triglycerides 33 percent, mean LDL 43 percent and increased HDL 10 percent.

Flushing symptoms were described as almost always tolerable. Only three subjects discontinued the study for niacin-related complaints and there was no indication of hepatotoxicity. Although not seen in this study, all niacin products carry the potential for liver function test elevations or hepatotoxicity, so monitoring is key.1

In summary, Slo-Niacin® was well-tolerated alone and in combination with Lipitor and benefitted all lipoprotein levels (HDL, LDL, and trigylcerides), as expected of niacin treatment.

About Slo-Niacin®

Slo-Niacin® Tablets (polygel® controlled-release niacin) are a niacin dietary supplement that have been trusted by healthcare professionals since 1988. Clinical trials have demonstrated that when dosed and monitored appropriately, Slo-Niacin® is complementary to statin therapy for cholesterol management, as demonstrated in the SLIM Study.1, 4

Slo-Niacin® is economical and often costs less than an insurance copayment. It is widely available at pharmacies and other retailers without a prescription as a dietary supplement. Slo-Niacin is available in three dosage strengths (250 mg, 500 mg and 750 mg) for individual dosing.3

Because Slo-Niacin® is a dietary supplement it is not intended to diagnose, treat, cure or prevent an
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SOURCE Upsher-Smith Laboratories, Inc.
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