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New Consortium to Develop Drugs for Neglected Tropical Diseases
Date:8/17/2009

rse as the rainforests in Central and South America to deserts in Asia and the Middle East. 350 million people are at risk of developing the disease, with as many as 12 million people worldwide being infected, and 1.5-2 million new cases occurring each year. Leishmaniasis presents in cutaneous, visceral and mucosal forms, with the visceral form of the disease alone having an estimated incidence of 500,000 new cases each year, and causing 60,000 deaths. Many different Leishmania species are implicated in the disease, which is transmitted by sand flies.

Neglected diseases framework

Neglected diseases such as African Sleeping Sickness, Leishmaniasis and Malaria, represent a major economic burden on developing countries. Within its project portfolio, TI Pharma is seeking to develop solutions to these diseases, mobilizing public and private partners in multilateral consortia - bringing together a wide range of competences and resources. This new project on phosphodiesterase is TI Pharma's sixth initiative in neglected diseases. Other projects focus on:

    - the development of a protective malaria vaccine;
    - a 'proof of concept' vaccine for Chikungunya;
    - an effective HIV therapy;
    - drug formulations that can resist tropical conditions without
      refrigeration for both oxytocin and insulin as well as vaccines for
      hepatitis B and influenza;
    - fixed dose combinations of formulations for drugs, applicable to
      combination therapies in many diseases, including neglected diseases.

For more information on TI Pharma's projects on neglected diseases, please visit http://www.tipharma.com/research/priority-medicines/neglected-diseases


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