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New Cimzia® (certolizumab pegol) Data Show a Significant, Rapid Clinical Response and Reduced Disease Activity Among Diverse Patient Populations With Active Rheumatoid Arthritis (RA)
Date:11/9/2010

CZP treatment group achieved ACR20 response versus the control group (25.9%).  Additional efficacy evaluated in the trial included ACR50/70 response rates, as well as the DAS28[CRP] disease activity score and the Health Assessment Questionnaire-Disability Index (HAQ-DI) measuring physical function.

Clinical responses among patients in the CZP treatment group were rapid. ACR 20/50 responses were significantly superior to control (31.8% vs 8.5% and 9.6% vs 1.4%, p<0.001 for both) from the first time point (week 2) onwards. Significant improvements in DAS28[CRP] were reported among patients treated with CZP vs. the placebo group.  In addition, CZP patients reported rapid and significant improvements in HAQ-DI vs. placebo at the first time point measured (week 2).

Similar ACR20 responses were seen across the various patient populations regardless of baseline disease duration or activity; baseline use of methotrexate; or prior use of TNF- inhibitors.  ACR50 and ACR70 responses at week 12 were 26.6% and 13% for patients treated with CZP compared to the placebo group (9.9% and 2.8% respectively).

Treatment with CZP was generally well tolerated. Adverse and serious adverse event rates were comparable between CZP and placebo treatment groups with no new safety signals observed through week 12.  The most common serious infections were lower respiratory tract and lung infections.   The most common adverse events were infections and infestations, musculoskeletal and connective tissue disorders, and nervous system disorders.

For full study information, please see:  http://www.abstracts2view.com/acr/titleindex.php?num=E&page=2 For further informationBert Kelly, Communication and Public Relations Manager, UCB404.784.6303, Bert.Kelly@ucb.comSarah Fox, Co
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