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New Article: Non-Patch, Transdermal Estrogen Products Such as Divigel(R) Are Effective Hormone Therapy Alternatives to Oral Estrogen
Date:1/27/2010

g estrogen, may be directly related to the compounding process." In 2005, the American College of Obstetricians and Gynecologists (ACOG) issued an opinion stating there was "no scientific evidence supporting the claims of increased efficacy or safety of individualized hormone therapy prepared by compounding pharmacies."(7)

About Transdermal Delivery Systems

Transdermal estrogen avoids first-pass metabolism, a process where the amount of a drug taken in is reduced before it reaches systemic circulation because a portion is metabolized in the liver. Avoiding first-pass metabolism allows for lower doses of hormones and establishes more consistent and more physiologic estrogen and metabolite blood levels. To achieve therapeutic levels, oral hormones require higher doses of estrogen than transdermals due to the first-pass metabolism in the liver.(2, 6)

Worldwide, the most commonly used transdermal delivery (TDD) systems for administering estradiol are patches and gels. Within the last few years, non-patch formulations of transdermal estrogen, such as Divigel®, have been developed that share the advantages of transdermal therapy but avoid the inconveniences of the patch, such as skin reactions to adhesives, disadhesion and visibility.(1) Studies have shown no difference in absorption, bioavailability, or peak concentrations between patches and gels, and administration of estradiol by non-patch transdermal therapies has been shown to provide consistent levels of serum estradiol.(4,5)

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SOURCE Upsher-Smith Laboratories, Inc.
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