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New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies
Date:12/18/2007

may not be effective against antibiotic-resistant strains of anthrax.

ABthrax is a human monoclonal antibody to Bacillus anthracis protective antigen that was discovered and developed by HGS, using technology that HGS has integrated into the Company as part of its collaboration with Cambridge Antibody Technology. ABthrax was the first investigational agent against anthrax infection to be evaluated in a clinical study following the 2001 anthrax attacks in the United States. In 2003, ABthrax received a Fast Track Product designation from the FDA, as well as an Orphan Drug Designation for its use in the treatment of inhalational anthrax disease.

In contrast to the anthrax vaccine, the protection afforded by a single dose of ABthrax would be immediate following the rapid achievement of appropriate blood levels of ABthrax. In contrast to antibiotics, ABthrax acts against the deadly toxins produced by anthrax bacteria. It may also prevent and treat infections by antibiotic-resistant strains of anthrax.

The ABthrax Contract with the U.S. Government

In June 2006, the U.S. Government exercised its option to purchase ABthrax for the Strategic National Stockpile (Contract Number HHS010020050006C). HGS expects to receive $165 million in revenues from this award, with the majority to come in 2008, when the Company begins to deliver ABthrax. The purchase award was made by the U.S. Department of Health and Human Services (HHS) under the Project BioShield Act of 2004, which is designed to accelerate the development, purchase and availability of medical countermeasures for the Strategic National Stockpile.

Under the contract, HGS will manufacture and deliver 20,000 treatment courses of ABthrax to the Strategic National Stockpile. The Company is also working closely with HHS, FDA and CDC to complete the additional laboratory and clinical testing required to support the filing of a Biologics License Application (BLA), and to support the use of ABthra
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SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
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