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New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies
Date:12/18/2007

- Human Genome Sciences' ABthrax(TM) shows lifesaving potential - - HGS on track to deliver 20,000 doses to Strategic National Stockpile

beginning in 2008 -

ROCKVILLE, Md., Dec. 18 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced that the results of two animal studies demonstrated the life-saving potential of its human monoclonal antibody drug ABthrax(TM) (raxibacumab). The results show that a single dose of ABthrax, administered without concomitant antibiotics, improved survival rates by up to 64 percent when administered after animals were symptomatic for anthrax disease as a result of inhalation exposure to massively lethal doses of anthrax spores. These dramatic and statistically significant findings demonstrate a survival benefit in two animal species, which is the requirement for establishing the efficacy of new drugs used to counter bioterrorism.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO )

"We believe that ABthrax offers a significant step forward in the treatment of inhalational anthrax, and could play an important role in strengthening America's arsenal against bioterrorism," said H. Thomas Watkins, President and Chief Executive Officer, HGS.

ABthrax, which specifically targets anthrax toxins and is being developed under contract with the Biomedical Advanced Research and Development Authority (BARDA), represents a new way to address the anthrax threat. While antibiotics can kill the Bacillis anthracis bacteria, they are not effective against the deadly toxins that the bacteria produce -- the real culprits in anthrax- related deaths. ABt
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SOURCE Human Genome Sciences, Inc.
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