Navigation Links
New Anti-TNF Study Shows Patients With Rheumatoid Arthritis Receiving REMICADE® After Inadequate Response to Enbrel® or Humira® Demonstrate Marked Clinical Improvement
Date:11/8/2010

ATLANTA, Nov. 8, 2010 /PRNewswire/ -- Patients with active moderate to severe rheumatoid arthritis (RA) inadequately responding to either etanercept (Enbrel®) or adalimumab (Humira®) and who were actively switched to REMICADE® (infliximab) demonstrated significant improvement from baseline at week 10, and sustained response through week 26 in an open label study. These week 26 results from the RESTART study were presented for the first time at the largest rheumatology medical meeting in the United States.

"These findings offer new insights into actively switching patients not responding to one TNF blocker to another therapy in the class, and in this case REMICADE," said Roy Fleischmann, MD, University of Texas/Southwestern Medical Center and lead investigator. "The data from the RESTART study show that there are patients switched to REMICADE who demonstrate immediate benefits, including improvements in disease activity and physical function."  

Patients who had an inadequate response (as measured by Disease Activity Score (DAS) 28 of at least 3.6 and at least 6 swollen and 6 tender joints) while receiving methotrexate and either etanercept or adalimumab were maintained on their stable dose of methotrexate and were actively switched to REMICADE 3 mg/kg. Patients who did not achieve or lost response had their dose titrated by 2 mg/kg.  At week 10, nearly half of REMICADE-treated patients (49.7 percent) achieved clinical response as evaluated by the European League Against Rheumatism (EULAR) response criteria. The EULAR response criteria are based on the assessment of disease activity using the DAS28 score, a statistically-derived index consisting of number of tender joints, number of swollen joints, erythrocyte sedimentation rate and global assessments of disease activity.  

At week 26, improvements were sustained (51.8 percent) with REMICADE maintenance dosing.  Simila
'/>"/>

SOURCE Centocor Ortho Biotech, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. New Anti-TNF Golimumab Significantly Reduced Signs and Symptoms of Ankylosing Spondylitis According to Phase 3 Study Findings
2. Phase 3 Data Show New Anti-TNF, Golimumab, Significantly Improved Arthritis, Skin and Nail Manifestations in Patients with Psoriatic Arthritis
3. Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis
4. New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients
5. SIMPONI(TM) (golimumab) Receives European Approval as Once-Monthly Subcutaneous Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis with Novel SmartJect(TM) Autoinjector
6. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
7. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
8. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
9. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
10. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
11. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... , July 28, 2015 On the ... the parent company of CPI International, Inc. (CPI), plans ... ended July 3, 2015 with the Securities and Exchange ... results for the quarter.  At 11 a.m. (EDT) on ... conference call in conjunction with this release that will ...
(Date:7/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cng4gn/refurbished ) has ... Market - Global Forecasts to 2019" report to ... market is estimated to grow expected to reach $9.37 ... 2014 to 2019. Factors such ... financial constraints, increasing privatization in the healthcare sector, and ...
(Date:7/28/2015)... 2015 A German Diabetes Center clinical study ... probiotic enriches human gut microbiota and modifies gut ... study involved daily administration of Nutraceutix,s L. reuteri ... patented BIO- tract ® delivery technology that ... their way to the intestinal tract. The ...
Breaking Medicine Technology:CPI International To Announce Third Quarter 2015 Financial Results 2Refurbished Medical Equipment Market 2015 - Global Forecasts to 2019 2Nutraceutix's L. reuteri Probiotic Clinically Proven to Modulate Gut Insulin Metabolism 2
... , CHICAGO, June 15 Vitamin D deficiency was found ... according to the results of a recent study conducted at ... Based on these results, CTCA researchers determined that screening for ... considered for all people with cancer. , , (Logo: ...
... JERUSALEM, Israel, June 15 ,The University of Pittsburgh ... announced today that the Institute has joined an elite,group of ... are now,enrolling patients to participate in the ExCell research study. ... assessing the safety and efficacy of StemEx(R), an,investigational product derived ...
Cached Medicine Technology:Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients 2UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients 2UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients 3
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... gateways, and embedded building blocks for edge devices that enable the Internet of ... 4th generation Intel® Core™ i7/i5 processor to provide exceptional computing power and multitasking ...
(Date:7/28/2015)... ... 2015 , ... opaJUMP! and O-PA! Performance Academy in ... associated with its training methods. This company is also the first to promise ... in early 2015, training yielded an average 80% improvement in functional health status ...
(Date:7/28/2015)... ... July 28, 2015 , ... Master flutist and solo artist Gary Stroutsos shares ... world, in this collection of serene, restorative instrumental music. Tracks carefully curated by ... for body work and more -- to help the listener deeply breathe in a ...
(Date:7/28/2015)... ... , ... Egg freezing is becoming an increasingly popular option for ... Dr. Michael Kettel explained in an article from the San Diego ... previous generations who had to make choices between their fertility and their career or ...
(Date:7/28/2015)... ... July 28, 2015 , ... According to Kxan on ... cycle of addiction in lab mice. The study involving isradipine has garnered national attention ... of helping their clients overcome drug and alcohol addictions. The study was conducted by ...
Breaking Medicine News(10 mins):Health News:ADLINK Launches High Performance, Fully-Sealed Medical-Grade Panel PC 2Health News:ADLINK Launches High Performance, Fully-Sealed Medical-Grade Panel PC 3Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 2Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 3Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 4Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 5Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 6Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 7Health News:Flute Meditations for Yoga & Massage: Calming Spa Music for Relaxation & Sleep by Gary Stroutsos 2Health News:Flute Meditations for Yoga & Massage: Calming Spa Music for Relaxation & Sleep by Gary Stroutsos 3Health News:Flute Meditations for Yoga & Massage: Calming Spa Music for Relaxation & Sleep by Gary Stroutsos 4Health News:Dr. Michael Kettel of San Diego Fertilty Center Interviewed by the San Diego Union-Tribune on Egg Freezing 2Health News:Dr. Michael Kettel of San Diego Fertilty Center Interviewed by the San Diego Union-Tribune on Egg Freezing 3Health News:Blood Pressure Medication May be the Key to Treating Addiction 2Health News:Blood Pressure Medication May be the Key to Treating Addiction 3
... found the brain region that controls the decision to ... enjoyment of that leftover chicken leg. Whats more, they ... malfunction in addiction and mental illness., Emmanuel Procyk and ... issue of the journal Neuron, published by Cell Press. ...
... to tap or press a surface is essential for ... a BlackBerry or an iPhone. But researchers at ... trivial action is the result of a complex neuro-motor-mechanical ... system and muscles of the hand. , USC ...
... use of stem cells for cardiac repair will be ... Heart Failure Association of the European Society of Cardiology ... experiments conducted with rodent engineered heart tissue (EHT) in ... for use in cardiac repair. Over one hundred top ...
... provides comparable relief, researchers say , , WEDNESDAY, Jan. ... treating low back pain, non-steroidal anti-inflammatory drugs (NSAIDs) ... effective than acetaminophen. , That,s the conclusion of ... included more than 11,000 people with low back ...
... ... - Medical enrollment grew by 708,000 members during 2007, - Selling, general and administrative expense ratio continued ... during the year, - Operating cash flow exceeded $4.3 billion for the year, or 1.3 times net ... income, - Company reiterates diluted earnings per share ...
... today at 10:00 a.m. EST by calling, ... the Web at: http://www.airproducts.com/Invest/financialnews/EarningsReleases.htm ... Products,(NYSE: APD ) today reported net income of ... for its fiscal first quarter ended December 31,2007. Net ...
Cached Medicine News:Health News:Researchers identify brain's 'eureka' circuitry 2Health News:What gives us fingertip dexterity? 2Health News:What gives us fingertip dexterity? 3Health News:NSAIDs No Better for Low Back Pain 2Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 2Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 3Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 4Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 5Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 6Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 7Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 8Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 9Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 10Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 11Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 12Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 13Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 14Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 15Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 16Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 17Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 18Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 19Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 20Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 21Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 22Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 23Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 2Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 3Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 4Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 5Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 6Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 7Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 8Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 9Health News:Air Products Reports Q1 EPS Up 16% on Volume Growth and Improved Margins; Raises 2008 Full Year EPS Guidance 10
... Ring Pessary is specifically ... urinary stress incontinence. The ... by stabilizing the bladder ... enhancement of urethral resistance ...
... The Cube pessary is ... including procidentia, as well as ... Cube pessary is available both ... and has a silicone tie ...
... Gehrung pessary has wires that allow ... different anatomies. It is used to ... well as second to third degree ... nine sizes. Because of the shapable ...
The Mar-Land is used for stress incontinence and minor prolapse. It is available both with and without support in seven different sizes....
Medicine Products: