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New Analysis Shows Potential Cost Savings of Adding Antiepileptic Drug Vimpat® C-V
Date:5/31/2011

BALTIMORE, May 31, 2011 /PRNewswire/ -- UCB announced findings of the first cost-effectiveness analysis of Vimpat® (lacosamide) as add-on therapy for adults with uncontrolled partial-onset seizures.  The findings were presented at the 16th International Society for Pharmacoeconomics and Outcomes Research (ISPOR) annual meeting in Baltimore, MD, USA.  

Researchers used a simulated pharmaco-economic model to analyze standard anti-epileptic drug therapy with and without lacosamide as add-on therapy in adults with uncontrolled partial onset seizures over a time horizon of two years in the United States.  The analysis found that treatment with lacosamide was associated with:

  • an incremental gain of 6,730 avoided seizures and 38 quality adjusted life years (QALY) for a cohort of 1,000 patients, compared to the standard therapy arm of the analysis
  • an estimated dollar value ranging from $223 to $733 per seizure avoided and an estimated dollar value of $39,574 per QALY gained, compared to the standard therapy arm of the analysis
  • 77% of patient simulations after 2 years of treatment fell within the acceptable thresholds of cost-effectiveness in the US, known as the willingness-to-pay threshold, which is $50,000 per QALY

QALY is a standard calculation used by health economists to compute a dollar amount for each additional year of life added by a therapy and a value for the quality of that life. In standard practice, if the QALY resulting from a therapy is less than $50,000 per year (the estimated value of a year of life in perfect health) then that therapy is seen as meeting the standard of willingness-to-pay.

"Cost- and utility-effectiveness analyses help to quantify the economic rationale for a treatment, which is an important factor in evaluating the use of a potential therapy," said Hicham Benhaddi, Senior Health Economist at UCB. "These findings provide addit
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SOURCE UCB
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