Navigation Links
New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease
Date:5/20/2008

subjects with disease duration less than three years, and 68 percent versus 34 percent for subjects with disease duration of at least three years; clinical remission: 28 percent versus 8 percent and 35 percent versus 12 percent, respectively; mucosal healing: 56 percent versus 29 percent and 63 percent versus 35 percent, respectively.

At week 30, clinical response, clinical remission and mucosal healing rates for the combined REMICADE treatment group (5 mg/kg and 10 mg/kg) were also significantly higher than the placebo group (P < 0.01) regardless of disease duration; clinical response: 49 percent versus 19 percent for subjects with disease duration less than three years, and 54 percent versus 34 percent for subjects with disease duration of at least three years; clinical remission: 28 percent versus 10 percent, and 35 percent versus 15 percent, respectively; mucosal healing: 47 percent versus 20 percent ,and 52 percent versus 32 percent, respectively. A Cochran-Mantel-Haenszel test stratified by baseline corticosteroid refractory status was used to compare REMICADE with placebo within each disease duration subgroup.

Ulcerative colitis is a chronic inflammatory disease of the colon and large intestine that affects approximately half a million Americans and can lead to frequent hospitalizations, surgery and loss of work productivity. Both UC and Crohn's disease are known collectively as inflammatory bowel diseases, or IBD. Approved in 1998 by the U.S. Food and Drug Administration as the first anti-tumor necrosis factor (TNF)-alpha therapy, REMICADE received its initial approval for the treatment of Crohn's disease and has since become the first and only anti-TNF-alpha therapy approved for the treatment of UC and pediatric Crohn's disease. A Phase 3 study evaluating the efficacy and safety of REMICADE for the treatment of pediatric UC is currently ongoing.

Impact of Anti-TNF Therapies on Absence from Work Among Employees with IBD

Also pres
'/>"/>

SOURCE Centocor
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
3. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
4. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
5. Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset
6. New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
7. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
8. Favrille Provides Update on Timing of Analysis from Pivotal Phase 3 Clinical Trial; Reports Third Quarter 2007 Financial Results
9. Results Of VYVANSE(TM) (lisdexamfetamine dimesylate) Effect Size Analysis Presented at Major Scientific Meeting
10. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
11. Retrospective Analysis Finds That Initiation of Insulin Glargine in Patients With Type 2 Diabetes was Associated With a Lower Incidence Rate of Myocardial Infarction as Compared With NPH Insulin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... CardioVascular Institute enrolled the first patient in Pennsylvania ... in a trial assessing the safety and effectiveness ... main artery of the leg. The new stent allows for ... stent fracture or re-narrowing after the stent is placed. ... the BioMimics 3D Stent System and will enroll 280 subjects ...
(Date:8/27/2015)... NEW YORK , Aug. 27, 2015   ... cord tissue , and placenta tissue ... innovative cord blood banking e-commerce website. This new website ... than ever with an interactive shopping cart and checkout ... "Most cord blood banking websites make this ...
(Date:8/27/2015)... 2015  Lightwave Logic, Inc. (OTCQB: LWLG), a ... Generation Photonic Devices and Non-Linear Optical Polymer ... fiber-optic data communications and optical computing, announced today ... appointed to the Company,s Board of Directors. ... optoelectronics is widely recognized with wide-ranging experience across ...
Breaking Medicine Technology:First Pennsylvania Patient Treated in Landmark Vascular Study 2Cord Blood Bank Revolutionizes Process of Online Cord Blood Banking 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3
... /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. (AMEX: ... manufacturer and distributor of botanical products, bio-pharmaceuticals and traditional ... made considerable progress in its efforts to comply with ... ("SOX 404") for fiscal year 2010. As ...
... Inc. (Nasdaq: PARD ), a biopharmaceutical company ... has completed the voluntary prepayment of the $12.35 million ... secured loan facility with GE Business Financial Services Inc. ... 16, 2010 that it had provided notice of such ...
Cached Medicine Technology:China Botanic Announces Progress on its SOX 404 Compliance Program 2China Botanic Announces Progress on its SOX 404 Compliance Program 3Poniard Pharmaceuticals Completes Voluntary Prepayment of Term Loans and Secures New Committed Equity Financing Facility 2Poniard Pharmaceuticals Completes Voluntary Prepayment of Term Loans and Secures New Committed Equity Financing Facility 3Poniard Pharmaceuticals Completes Voluntary Prepayment of Term Loans and Secures New Committed Equity Financing Facility 4
(Date:8/27/2015)... , ... August 27, 2015 , ... In the addiction ... leaving weeks or months later, relapsing and returning again, all at great cost to ... while in sober living homes or soon after leaving facilities who claim to have ...
(Date:8/27/2015)... CA (PRWEB) , ... August 27, 2015 , ... ... array of instruments available for quantitative PCR (qPCR) in the last ... higher throughput and reduced operating costs. On the flipside, where do lab managers, ...
(Date:8/27/2015)... ... , ... According to an article published August 19 on Healio, ... educate doctors and patients on the best practices for type 2 diabetes care. The ... the new version is taking into account nearly a decade of recent research data. ...
(Date:8/27/2015)... ... August 27, 2015 , ... Thriveology Founders, Dr. Carly Letzt Carney ... The Amazing Aging Expo in Denver, Colorado on Saturday, August 29, 2015 at the ... in media outlets as health authorities, and will present a two part seminar entitled, ...
(Date:8/27/2015)... , ... August 27, 2015 , ... ... enter the exploding legal marijuana industry with the launch of its Doobster platform, ... legal marijuana to order products from their smart phones and tablets. Well, ...
Breaking Medicine News(10 mins):Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 3Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 2Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 3Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 2Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 3Health News:Internationally-renowned Naturopathic Doctor and Chiropractor Team up to Reveal Secrets of Avoiding Disease 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5
... Non-profit organization RAND Corp. has come out with a finding ... who tend to use substance like marijuana, alcohol, and cigarettes ... a younger age, and to have a harder time quitting, ... setting or in groups. ,The results stem from ...
... on the dead skin of visitors' feet is turning into ... // ,Hordes of Turkish spa fish, members of the ... first Fish Reflexology spot at the Underwater World attraction., ... skin are removed by the fish., ,It costs $22 ...
... the scheme 'Assistance for capacity Building', Ministry of ... a maximum //of Rs. 1.50 crores or actual, ... emergency facilities of State Hospitals of towns/cities located ... NHAI, Department of Road Transport and Highways and ...
... Board of Health in a surprise move went back ... change the sex on their birth //certificates, without physically ... seconded by mental health professionals and transgender supporters, who ... discrimination against people who desire to adopt the 'opposite' ...
... A draft report from NHS Institute for Innovation and Improvement ... by GPs and visiting //nurses rather than admitting them in ... a range of conditions regularly seen in Accident and Emergency ... more could be done for reducing the numbers admitted in ...
... by the Department of Radiology at the University of ... the accuracy of diagnosing meniscal tears. ... there is one MR image with an abnormal finding. ... of 174 patients who had knee MR exams then ...
Cached Medicine News:
Aerosolized Medication Device for Infants. An alternative to aerosol blow-by., ,The PediNeb™ was designed to enhance the delivery of aerosolized medication, while reducing the apprehension enc...
... and Respiratory Products, ,Westmed designs, manufacturers ... Anesthesia and Respiratory professionals. Our mission is ... the clinician's ability to deliver quality medical ... bottom line. , ,Our web site ...
... Applications:, ,Cool Aerosol Therapy. Replaces air ... devices such as aerosol masks, face tents, ... only limited FIO2 and limited flow. The ... against accidental dilution with room air or ...
... For use with metered dose inhalers., ... medication from MDI canisters. Its versatile design ... ventilator circuit, in conjunction with an endotracheal ... oral inhalation. ACE may also be used ...
Medicine Products: