Navigation Links
New Analysis Shows Age has a Significant Effect on Outcomes in Patients Being Treated for Clostridium difficile Infection (CDI)
Date:2/14/2013

nd other factors that may impact treatment outcome, including the administration of concomitant antibiotics and C. difficile strain, DIFICID was associated with a 60% lower risk of recurrence (p<0.001) compared to vancomycin.

"This analysis reinforces the serious consequences of CDI for patients as they get older, including significantly increased risk of disease recurrence and treatment failure, " said Sherwood L. Gorbach , M.D., co-author and Optimer's Chief Scientific Officer and Senior Vice President. "Most notably, results showed that the decline in treatment outcomes can begin as early as age 40, which suggests that age is an important risk factor for patients."

About the Analysis
The analysis was based on two multi-center, randomized, double-blind Phase 3 clinical trials, which enrolled 1,164 adult patients throughout Europe and North America. Patients with confirmed CDI,  received either 200 mg of DIFICID (fidaxomicin) tablets dosed orally twice daily or 125 mg of vancomycin dosed orally four times daily for 10 days.  

CDI was defined by a change in bowel habits, with more than three unformed bowel movements (or >200 mL unformed stool for patients with rectal collection devices) in the 24 hours before randomization, and the presence of either toxin A or B of C. difficile in the stool within 48 hours of randomization. The primary endpoint of the study was non-inferiority in clinical cure, which was defined as resolution of diarrhea (no more than three unformed stools for two consecutive days) maintained until the end of therapy for two days after. Patients who achieved a clinical cure were monitored for a subsequent four-week period to evaluate recurrence, which was a secondary endpoint.  Sustained clinical response, an additional endpoint, was defined as patients who achieved clinical cure and did not experience a recu
'/>"/>

SOURCE Optimer Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Ventana Receives FDA Clearance for p53 (DO-7) Image Analysis and Digital Read Applications
2. Global Ablation Technologies Market (2011-2016) - By Application and Devices in Radiofrequency, Cryoablation, Microwave, Ultrasound, Hydrothermal, Radiation, Electrical, Light/Laser and Hydromechanical - Global Trends & Competitive Analysis
3. Osteoporosis Drug Market- Global And China Market Analysis, Size, Trends And Forecast (2010-2015)
4. Large-Scale Meta-Analysis Shows Age Not a Social Barrier to Opioid Use and Misuse
5. Purdue Pharma L.P. To Present Analysis Of Butrans® (buprenorphine) Transdermal System CIII Clinical Data At American Pain Society Annual Meeting
6. Negative Pressure Wound Therapy (NPWT) - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2018
7. Demand for Product Pipeline Review and Analysis Rises in the Global Pharma Industry
8. Lifeline Biotechnologies, Inc. Receives Patent Award, a Device for Breast Tissue Temperature Analysis for Determining Cancer Conditions
9. Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020
10. Clinical Chemistry Market Report & Forecast (2012 - 2015): Global Analysis
11. Medical Diagnostic & Therapeutic Ultrasound Devices Market (2012 - 2017) - Global Trends & Competitive Analysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Revenue and earnings above the previous ... development In the past 2013/14 fiscal year (ended ... to EUR 4.287 billion (last year: EUR 4.190 billion) despite ... EUR 360 million. "Overall, 2013/14 was a successful fiscal year ... President and CEO of Carl Zeiss AG. "Thanks to our ...
(Date:12/17/2014)... With advancements in neurological and functional ... seeing new growth, according to Kalorama Information. Though ... the majority of market volume, newer 3T systems ... are creating opportunities for more sophisticated applications. The medical ... a rate of 4%, with world market revenues ...
(Date:12/17/2014)... Dec. 17, 2014  ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... and Trademark Office (USPTO) has issued a key ... cell-based immunotherapeutic vaccine targeting six tumor antigens that ... US Patent No. 8,871,211, which issued October 28, ... administering a dendritic cell composition comprising peptide epitopes ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... AUGUSTINE, Fla., Aug. 10, 2011 Flagler Hospital ... selected the Sunrise Enterprise ™ suite of clinical ...  In addition to implementing Sunrise within the hospital, Flagler ... Record (EHR) and practice management solution for its ...
... Simbionix USA Corporation, the world,s leading provider of ... and the healthcare industry, is pleased to announce it ... its innovative PROcedure Rehearsal Studio ™ . ... in industry product, allowing clinicians to create patient specific 3D ...
Cached Medicine Technology:Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 2Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 3Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 4Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 5Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 6Patent Granted for Simbionix Procedure Rehearsal Studio™ 2
(Date:12/21/2014)... 21, 2014 AngelWeddingDress.com’s new collection of ... a total of 1,000 new designs in this collection, ... spring 2015. , AngelWeddingDress.com promises to provide ... with wardrobe essentials while many fashion trends come and ... customer service team at AngelWeddingDress.com is ready to assist. ...
(Date:12/21/2014)... Mi (PRWEB) December 21, 2014 AlignLife ... child in need while at the same time helping people ... is a non-profit community-based organization committed to serving those persons ... meet their needs to improve the quality of life. Dr. ... make an impact in the local community and he knew ...
(Date:12/21/2014)... December 21, 2014 Theme ... a new intro plugin for Final Cut Pro X ... videos, logos, and more with absolute ease.” Said Christiana ... users the tools needed to easily animate their media ... Cut Pro X users to animate pictures, videos, logos, ...
(Date:12/20/2014)... BambooIndustry.com is a professional company offering ... has recently shown its new engineered bamboo flooring collection, ... flooring models. , BambooIndustry.com’s customers come from many countries ... According to the CEO of the company, the global ... the past few years, and the demand for eco-friendly ...
(Date:12/20/2014)... Dress company LunaDress has recently announced its ... Christmas Sale, offering big discounts on all of its special ... idea to own a perfect wedding gown. If you have ... then come to LunaDress. Many different wedding dress styles and ... website now and enjoy the current special offer, up to ...
Breaking Medicine News(10 mins):Health News:2015 Spring Wedding Dresses From AngelWeddingDress Just Released 2Health News:AlignLife of Norton Shores Makes a Brighter Christmas for Kids in Muskegon 2Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:BammbooIndustry.com: Big Discounts On All Kinds Of Bamboo Flooring Collections 2Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2
... 30, PharmAthene, Inc. (NYSE Amex: PIP ... and chemical threats, today reported operational and financial results ... years ended December 31, 2008 and 2007, the Company ... Revenues for the full year 2008 consisted primarily ...
... new studying appearing in Congenital Heart Disease ... and women who underwent surgery for congenital heart disease ... produced evidence that shows how medicine may provide preconditions ... life. , In recent decades, survival rates and the ...
... for fiscal fitness.DOVER, N.H., March 30 No more excuses! Planet ... during these tough economic times. From April 1 - April ... members will pay a one-dollar sign-up fee and ... All are encouraged to register either online at ...
... chemicals used to make bombs can foil detection because ... detection techniques. Tel Aviv University has developed the ultimate ... "hidden" molecules into something we can detect and see. ... Shabat of TAU,s Raymond and Beverly Sackler School of ...
... Newsletter for Healthcare ProfessionalsVOORHEES, N.J., March 30 ... urticaria (hives) and angioedema can be challenging, ... a number of immunologic and nonimmunologic mechanisms. ... seemingly identical presentation of angioedema subtypes. It ...
... check-in, ,self-room, access medical information and learn about ... new portable terminal used by patients during hospital, ... and streamline patient check-in, plus provides doctors, nurses ... enhancing tool. International Medical Solutions has introduced ...
Cached Medicine News:Health News:PharmAthene Reports Year End 2008 Financial Results 2Health News:PharmAthene Reports Year End 2008 Financial Results 3Health News:PharmAthene Reports Year End 2008 Financial Results 4Health News:PharmAthene Reports Year End 2008 Financial Results 5Health News:PharmAthene Reports Year End 2008 Financial Results 6Health News:PharmAthene Reports Year End 2008 Financial Results 7Health News:Study examines effect of heart surgery on employment 2Health News:A 'bionic nose' that knows 2Health News:New Directions in Angioedema: A Focus on Pathogenesis and Classification 2Health News:New Mobile Patient Communicator(TM) Gives Patients an Interactive Education Tool and Boosts Nurse Productivity 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: