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New Analysis Shows Age has a Significant Effect on Outcomes in Patients Being Treated for Clostridium difficile Infection (CDI)
Date:2/14/2013

JERSEY CITY, N.J., Feb. 14, 2013 /PRNewswire/ -- Optimer Pharmaceuticals, Inc. (Nasdaq: OPTR) today announced that the February 2013 Journal of the American Geriatrics Society published results from a multivariate analysis demonstrating that advancing age is a predictor of deterioration in treatment outcomes in patients with Clostridium difficile infection (CDI). The analysis was performed using data from two large, randomized Phase 3 clinical studies that compared the efficacy of DIFICID® (fidaxomicin) tablets to vancomycin for the treatment of CDI. The new analysis predicts that with each decade increase after the age of 40, rates of clinical cure and sustained clinical response decrease by 17% and 13% with treatment, respectively, per decade (OR=0.83, 95% CI [0.72, 0.95], p=0.008; and OR=0.87, 95% CI [0.79, 0.94], p<0.001), while rates of disease recurrence increase by 17% (OR=1.17, 95% CI [1.04, 1.30], p=0.007). 

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Results of the analysis showed that DIFICID and vancomycin were comparably effective in attaining clinical cure in all age groups studied; in those younger than 40 years of age, clinical cure was achieved in 97.2% of patients and in those older than 80, clinical cure was achieved in 87.5% to 88.2% of patients. For patients who achieved clinical cure, DIFICID-treated patients were half as likely to have had a recurrence compared to patients treated with vancomycin (OR=0.46, 95% CI [0.32, 0.67], p<0.001). The analysis showed the probability of sustained clinical response nearly doubled among DIFICID-treated patients compared to patients who received vancomycin (OR=1.86, 95% CI [1.40, 2.47], p<0.001). When researchers conducted an analysis adjusting for age a
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SOURCE Optimer Pharmaceuticals, Inc.
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