Navigation Links
New Analysis Assesses Impact of Common Genetic Variation on Benefit of Antiplatelet Therapy
Date:3/15/2010

PARSIPPANY, N.J. and INDIANAPOLIS, March 15 /PRNewswire-FirstCall/ -- A new analysis of the TRITON-TIMI 38 study evaluated response rates in patients with a common genetic variant in the ABCB1 gene. Patients enrolled in the TRITON-TIMI 38 study were treated with dual antiplatelet therapy with either Plavix® (clopidogrel) plus aspirin or Effient® (prasugrel) plus aspirin and managed with percutaneous coronary intervention (PCI) following an acute coronary syndrome (ACS) event. The results of this retrospective genetic sub-study were presented today at the American College of Cardiology annual meeting.

The ABCB1 gene contains the genetic code for a protein (P-glycoprotein) that plays an important role in how the body absorbs many medications, including antiplatelet drugs. Genetic variants in ABCB1 may reduce response to antiplatelet therapy.

In this sub-study, the TRITON-TIMI 38 investigators analyzed clinical outcomes among 2,943 patients tested for the "C3435T" variant in the ABCB1 gene. More than one out of four (27 percent) patients in the analysis were found to have two C3435T variants in their chromosomes.(1) Clopidogrel-treated patients who had two C3435T variants (n=414) had a 66 percent increased risk of experiencing the primary composite endpoint of cardiovascular death, heart attack or stroke compared to clopidogrel-treated patients without the variant (12.9 percent vs. 8.2 percent, HR=1.66; p=0.033). The overall A
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
3. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
4. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
5. Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset
6. New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
7. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
8. Favrille Provides Update on Timing of Analysis from Pivotal Phase 3 Clinical Trial; Reports Third Quarter 2007 Financial Results
9. Results Of VYVANSE(TM) (lisdexamfetamine dimesylate) Effect Size Analysis Presented at Major Scientific Meeting
10. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
11. Retrospective Analysis Finds That Initiation of Insulin Glargine in Patients With Type 2 Diabetes was Associated With a Lower Incidence Rate of Myocardial Infarction as Compared With NPH Insulin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... , Sept. 19, 2014  CytRx Corporation (Nasdaq: ... specializing in oncology, today announced that David J. ... BioCentury,s 2014 NewsMakers in the Biotech Industry Conference on Friday, ... The conference will take place at the Millennium Broadway ... A live and archived webcast of the ...
(Date:9/19/2014)... -- Reductions in kidney failure obtained during ... with diabetes type 2 "Intensive treatment is ... kidneys." Australian researchers have discovered that intensive ... to persistent reductions in kidney failure many years after ... has found that, five and a half years after ...
(Date:9/18/2014)... September 19, 2014 ... http://www.researchandmarkets.com/research/qqjrnh/global_molecular ) has announced the addition of ... report to their offering. ... the study of chromosomes using molecular biology ... genes and chromosomes. It plays a crucial ...
Breaking Medicine Technology:CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 2CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 3ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3Global Molecular Cytogenetics Market 2014-2018: Key Vendors are Abbott, Affymetrix, Agilent Technologies, F. Hoffmann-La Roche, Illumina and PerkinElmer 2Global Molecular Cytogenetics Market 2014-2018: Key Vendors are Abbott, Affymetrix, Agilent Technologies, F. Hoffmann-La Roche, Illumina and PerkinElmer 3
... /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. (NYSE AMEX: ... "Company"), a developer, manufacturer and distributor of botanical ... China, today announced that the Company,s Badger Oil, ... Pharmaceutical Co., Ltd ("Renhuang"), has achieved sales of ...
... Alison MacNeil issued the following statements today regarding ... PBS this week: "When I vaccinated ... are not required to test the safety of vaccines ... thousands of parents with Autistic children report that, like ...
Cached Medicine Technology:China Botanic Pharmaceutical Provides Update on Badger Oil Sales 2China Botanic Pharmaceutical Provides Update on Badger Oil Sales 3Daughter of Journalist Robert MacNeil States that Son Regressed Into Autism After Vaccines 2
(Date:9/19/2014)... Red Bank, NJ (PRWEB) September 19, 2014 ... Jersey’s largest not-for-profit provider of home health care, hospice ... join Deutsche Bank to ring the Opening Bell yesterday ... 1912 by a New Jersey philanthropist and social entrepreneur ... other diseases, VNA Health Group has always worked to ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Boston Scientific ... mesh lawsuit ( http://www.transvaginalmeshlawsuithelp.com/ ) that is scheduled ... month, Bernstein Liebhard LLP reports. According to ... Court, the company asserts that claims involving its Solyx ... Practice and Remedies Code, a section of which shields ...
(Date:9/19/2014)... Sept. 19, 2014 (HealthDay News) -- Your brain structure could ... a new study suggests. Researchers at Yale University found ... known as the parietal cortex may be more likely to ... this area. , , The study, funded by the U.S. ... men and women living in the Northeast. The researchers sought ...
(Date:9/19/2014)... News) -- Although there is mounting evidence that ... and older adults in the United States don,t ... new research. Less than one-quarter of adults ... the Department of Health and Human Services, the ... promoting health and fitness and staying independent, researchers ...
(Date:9/19/2014)... HealthDay Reporter THURSDAY, ... by stress and family conflicts before surgery may face ... new study suggests. Investigators found that patients with ... three times greater risk for complications compared to those ... "We,ve long known that patient quality of life is ...
Breaking Medicine News(10 mins):Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3Health News:Transvaginal Mesh Lawsuit Defendant Moves For Summary Judgment in Case Scheduled for Upcoming Texas Trial, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit Defendant Moves For Summary Judgment in Case Scheduled for Upcoming Texas Trial, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuit Defendant Moves For Summary Judgment in Case Scheduled for Upcoming Texas Trial, Bernstein Liebhard LLP Reports 4Health News:Brain Structure Might Help Predict Risky Behavior 2Health News:Adults Over 45 Not Meeting U.S. Muscle Strengthening Guidelines, Study Says 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 2Health News:Family Squabbles Can Derail Recovery From Cancer Surgery 3
... that food rich in carbohydrates was very effective in maintaining ... are to be presented at the Australian //Institute of Food ... study was conducted by the University of Melbourne research dietician ... obese people for a period of 12 weeks. ...
... 2 diabetes over a period of 22 years have revealed ... This has helped to highlight the need ... Dr. Mohsen Janghorbani from Isfahan University of Medical Sciences in ... a consequence of diabetes mellitus. However, this study, as well ...
... research has revealed that men and women often respond differently ... gene behavior in the organs of males and females//. ... humans, have been used as the subjects of the study ... tissue. The results of the research have been published in ...
... treating patients with mouth and throat cancer with ‘Manuka honey’, ... at the Manchester cancer hospital explained that the honey is ... Hospital in Didsbury, Manchester, are planning to use it on ... They hope to try and reduce the patient’s chances of ...
... Dr. P. Venugopal won a reprieve on Friday when ... Institute's Governing Body recommending his sacking.// ,'The decision ... Venugopal's services, is stayed and the government is restrained ... Kumar said in his order. ,He issued ...
... to introduce new legislation to regulate doctors, due to be ... seeking Government approval in order to publish heads of bill ... that a new Medical Practitioners Bill can be published later ... Act have been promised and postponed for many years, it ...
Cached Medicine News:Health News:Diabetic Women Show Increased Risks of Hip Fracture 2
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
... Indirect Ophthalmoscope Power Source provides power to ... ophthalmic instruments. The versatile wall/desk power source ... or on the side of a desk ... portable power pack provides power no matter ...
The Welch Allyn 125 BIO is designed to achieve precise binocular viewing and stereopsis easier than ever before. Its observation paths can be adjusted from 48 mm to 74 mm to handle the widest and nar...
Medicine Products: