Navigation Links
New Analysis Assesses Impact of Common Genetic Variation on Benefit of Antiplatelet Therapy
Date:3/15/2010

PARSIPPANY, N.J. and INDIANAPOLIS, March 15 /PRNewswire-FirstCall/ -- A new analysis of the TRITON-TIMI 38 study evaluated response rates in patients with a common genetic variant in the ABCB1 gene. Patients enrolled in the TRITON-TIMI 38 study were treated with dual antiplatelet therapy with either Plavix® (clopidogrel) plus aspirin or Effient® (prasugrel) plus aspirin and managed with percutaneous coronary intervention (PCI) following an acute coronary syndrome (ACS) event. The results of this retrospective genetic sub-study were presented today at the American College of Cardiology annual meeting.

The ABCB1 gene contains the genetic code for a protein (P-glycoprotein) that plays an important role in how the body absorbs many medications, including antiplatelet drugs. Genetic variants in ABCB1 may reduce response to antiplatelet therapy.

In this sub-study, the TRITON-TIMI 38 investigators analyzed clinical outcomes among 2,943 patients tested for the "C3435T" variant in the ABCB1 gene. More than one out of four (27 percent) patients in the analysis were found to have two C3435T variants in their chromosomes.(1) Clopidogrel-treated patients who had two C3435T variants (n=414) had a 66 percent increased risk of experiencing the primary composite endpoint of cardiovascular death, heart attack or stroke compared to clopidogrel-treated patients without the variant (12.9 percent vs. 8.2 percent, HR=1.66; p=0.033). The overall A
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
3. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
4. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
5. Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset
6. New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
7. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
8. Favrille Provides Update on Timing of Analysis from Pivotal Phase 3 Clinical Trial; Reports Third Quarter 2007 Financial Results
9. Results Of VYVANSE(TM) (lisdexamfetamine dimesylate) Effect Size Analysis Presented at Major Scientific Meeting
10. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
11. Retrospective Analysis Finds That Initiation of Insulin Glargine in Patients With Type 2 Diabetes was Associated With a Lower Incidence Rate of Myocardial Infarction as Compared With NPH Insulin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014  A substantial share ... decisions about which therapies are included in formularies—say ... according to a new Manhattan Research study, ... The study finds that P&T committee members in ... managers (PBMs) have set a high bar for ...
(Date:7/31/2014)... , July 31, 2014 Lazarus Effect, ... novel interventional devices to facilitate removal of blood clots, ... from the financing will support EU commercialization of several ... for the Lazarus ReCover™ and Lazarus Cover™ in ... financing reflects investor confidence in the value of our ...
(Date:7/31/2014)... -- For its innovative modular Biomedical Research building in ... has earned a Modular Building Institute (MBI) 2014 Award ... categories, MBI,s contest is the commercial modular industry,s premier ... dealers, and product and service providers. ... our team," said Dan Palmer , President of ...
Breaking Medicine Technology:Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3Lazarus Effect Closes $5 Million Financing 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 3Art's Way Scientific Earns Prestigious Modular Building Institute Award 4
... Incorporated (Nasdaq: ARAY ), a global leader ... company has established a Medical Affairs function to accelerate ... provide strategic guidance on clinically driven processes, innovations and ... Accuray has been focused on driving innovation that meets ...
... Millennium Pharmacy Systems, Inc. has announced that Philip ... Vice President and Chief Operating Officer based in its ... 29, 2010. Mr. Keough brings over twenty ... consulting experience to Millennium. He most recently led Keoco, ...
Cached Medicine Technology:Accuray Establishes Medical Affairs Function 2Accuray Establishes Medical Affairs Function 3Pharmacy Industry Veteran Joins Millennium Pharmacy Systems as COO 2
(Date:7/31/2014)... 2014 United Theological Seminary is pleased ... Le Donne and Peter J. Bellini. Both began their ... United is a Director of Non-Degree Programs, Mark Abbott, ... Anthony Le Donne, Assistant Professor of New Testament, received ... New Testament, Second Temple Judaism, and Greek courses. His ...
(Date:7/31/2014)... Cosmetic Town is a new web directory ... considering cosmetic treatments. The site features doctors who ... to educate prospective patients on a variety of cosmetic ... referral system that helps patients find cosmetic specialists in ... fields. , Cosmetic Town started its recruitment of ...
(Date:7/31/2014)... The VitaSleep FDA cleared anti-snoring device ... an easier breathing capacity by slightly adjusting the position ... can breathe easier and helps reduce or even completely ... it can meet the needs of each individual snorer. ... by actual customer reviews. Johathan R. from Statham ...
(Date:7/31/2014)... Ce-Classes.com has developed a Learning Management ... to pass inspections and audits. Ce-Classes.com can ... accreditation and state licensing criteria by providing their ... administrators can monitor employee compliance with mandatory training ... can be developed based on the policies and ...
(Date:7/31/2014)... Andrie, Inc. V. Dept. of Treasury, Mich. S. ... has made the determination that a purchaser of tangible goods ... was unable to prove during an audit that sales ... Court of Appeals decision on whether a purchaser bears the ... purchases from Michigan sellers. The Court states “in order to ...
Breaking Medicine News(10 mins):Health News:Growing Seminary Welcomes New Faculty 2Health News:The New Doctors’ Directory, Cosmetic Town Does the Research for Consumers of Plastic Surgeries 2Health News:New Dental Device Reviews to Stop Snoring by VitalSleep 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 3Health News:Taxpayer Failing To Prove Sales Tax Was Paid At Time Of Purchase Results In Use Tax Due 2Health News:Taxpayer Failing To Prove Sales Tax Was Paid At Time Of Purchase Results In Use Tax Due 3
... Health Care, a leading,regional not-for-profit health insurer with ... New Hampshire, has selected IncentOne, the leading,provider of ... and,Preferred Care health plan members through the health ... plans that utilize the "WellStyle Extras",option, now can ...
... their teachers from four counties, San,Bernardino, Riverside, Inyo and ... Nov. 6 On Sunday, November 9,2008 at 1 ... Stater Bros. Markets, in conjunction with KFRG radio stations ... children on the field,of the Arrowhead Credit Union Stadium ...
... interfere with mechanisms that inhibit cell regeneration , , THURSDAY, Nov. ... and brain can,t be repaired now if they are severed ... again are being proposed by separate groups of researchers. , ... the built-in mechanisms that prevent nerve cell regeneration. One approach ...
... Medicaid Health Plans of,America (MHPA), the leading ... plans, today extended its congratulations to,President-Elect Barack ... the 44th,President of the United States., ... historic,victory," stated MHPA,s Executive Director Thomas L. ...
... rights for members and,non-union workers, SACRAMENTO, Calif., Nov. ... by more than 97 percent to approve a,groundbreaking new ... workers that are far ahead of the rest of ... Healthcare Workers-West (UHW) won the,agreement with their employer after ...
... Product for Hands Helps Improve Healing, Reduce ... Post-Op ... Ready(TM) announced today,the release of its breakthrough Hand Wrap for ... The Hand Wrap,dramatically increases physicians, and patients, treatment options by,extending ...
Cached Medicine News:Health News:MVP Health Care and IncentOne Partner to Provide Member Incentives for MVP and Preferred Care 'WellStyle Extras' Program 2Health News:Stater Bros. Charities, KFRG Radio Stations and Loma Linda University Children's Hospital Will Present More Than 1,100 Brand-New Bikes to 4th Grade Students! 2Health News:New Pathways Studied to Repair Nerves 2Health News:New Pathways Studied to Repair Nerves 3Health News:United Healthcare Workers Win New Contract with Horizon West 2Health News:United Healthcare Workers Win New Contract with Horizon West 3Health News:Game Ready(TM) Announces New Hand Treatment 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: