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New Analyses Indicate that Divigel(R) (estradiol gel) 0.1% Is a Valuable Option for Certain Postmenopausal Women With Hot Flashes
Date:9/25/2008

ffects of treatment may be most appreciable in women over age 50.

The third abstract used the same patient population to investigate the effect of body mass index (less than or equal to 30, > 30) and BMI plus Divigel(R) (1.0 g/day, 0.5 g/day, 0.25 g/day) combined compared to placebo on the change from baseline to week 12 in the frequency and severity of hot flashes. Results indicated that body mass index had a significant interaction with treatment on both the frequency (P =0.036) and severity (P =0.019) of hot flashes, whereas, normal/overweight women experienced a significant reduction in both the frequency and severity of hot flashes (P <0.0001).

"Estrogen therapies, such as Divigel(R), continue to be the gold standard for the management of hot flashes and transdermal therapies, in particular, are emerging as safe and effective alternatives for women experiencing the most common physical sign of menopause," said Dr. Ackerman.

The estrogen in Divigel(R) is derived from plant sources and is identical to the primary estrogen produced by a woman's ovaries before menopause. Divigel(R) is a quick-drying gel that is odorless when dry, and is available in convenient, individual-use packets. One packet of gel is applied daily to an area that measures approximately 5 x 7 inches on the thigh, the smallest application area compared to all other available gel or lotion estrogen products. Divigel(R) also offers dosing flexibility with three different strengths (0.25 mg estradiol/day, 0.5 mg estradiol/day and 1.0 mg estradiol/day) to individualize treatment for each woman.

For more information, call 1-800-654-2299 or visit http://www.divigelus.com.

Important Safety Information

Estrogens should not be used in women with undiagnosed abnormal vaginal bleeding; known, suspected, or history of breast cancer; known or suspected estrogen-dependent neoplasia; active or history of deep vein th
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SOURCE Upsher-Smith Laboratories, Inc.
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