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New 48-Week Efficacy and Safety Data Presented for INTELENCE(TM) (etravirine) as Part of HIV Combination Therapy
Date:2/7/2008

avir,

full-dose ritonavir (600 mg bid), protease inhibitors administered

without ritonavir, and other NNRTIs

-- INTELENCE should not be co-administered with carbamazepine,

phenobarbital, phenytoin, rifampin, rifapentine, rifabutin (when part

of a regimen containing protease inhibitor/ritonavir) or products

containing St. John's wort (Hypericum perforatum)

-- INTELENCE and lopinavir/ritonavir should be co-administered with

caution

-- Co-administration of INTELENCE with other agents such as substrates,

inhibitors, or inducers of CYP3A4, CYP2C9, and/or CYP2C19 may alter

the therapeutic effect or adverse events profile of INTELENCE or the

co-administered drug(s). This is not a complete list of potential drug

interactions

Please see full Prescribing Information for more details at INTELENCE-info.com.

About INTELENCE

INTELENCE was developed by Tibotec Pharmaceuticals Ltd. and is marketed in the U.S. by Tibotec Therapeutics, a division of Ortho Biotech Products, L.P. Applications for approval of INTELENCE have been submitted to the European Agency for the Evaluation of Medicinal Products (EMEA) and to regulatory authorities in other countries, including Canada, Switzerland, Russia, Australia, and South Korea.

Tibotec Therapeutics

Tibotec Therapeutics, a division of Ortho Biotech Products, L.P., a subsidiary of Johnson & Johnson, headquartered in Bridgewater, N.J., is dedicated to delivering innovative virology therapeutics that help healthcare professionals address serious unmet needs in people living with HIV.

Tibotec Pharmaceuticals Ltd.

Tibotec Pharmaceuticals Ltd., a subsidiary of Johnson & Johnson, based in Cork, Ireland, is a pharmaceutical research and development company. The Company's main research and development facilities are in Mechelen, Belgium with offices in Yardley, PA. Tibotec is dedicated to the di
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SOURCE Tibotec Therapeutics
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