Navigation Links
New 48-Week Efficacy and Safety Data Presented for INTELENCE(TM) (etravirine) as Part of HIV Combination Therapy
Date:2/7/2008

acebo (604 patients), each given in addition to a BR. For all patients, the BR included darunavir/ritonavir, plus at least two investigator-selected antiretroviral drugs (N(t)RTIs with or without enfuvirtide). The study remained double-blinded through 48-weeks.

48-Week Efficacy Findings

-- In DUET-1, 60 percent of patients in the INTELENCE arm had a confirmed

undetectable viral load at 48 weeks compared with 39 percent of those

in the placebo arm [p<0.0001].

-- In DUET-2, 61 percent of patients in the INTELENCE arm had a confirmed

undetectable viral load at 48 weeks compared with 41 percent of those

in the placebo arm [p<0.0001].

-- In DUET-1, the mean increase in CD4+ cell count from baseline was

103 cells/mm3 in the INTELENCE arm compared with 74 cells/mm3 in the

placebo arm [p=0.0025].

-- In DUET-2, the mean increase in CD4+ cell count from baseline was

94 cells/mm3 in the INTELENCE arm compared with 72 cells/mm3 in the

placebo arm [p=0.0160].

48-Week Safety Findings

In DUET-1, the most commonly reported adverse events among patients in the INTELENCE arm vs. placebo arm were rash of any type (22 percent vs. 11 percent), diarrhea (14 percent vs. 24 percent), and nausea (15 percent vs. 15 percent).

In DUET-2, the most commonly reported adverse events among patients in the INTELENCE arm vs. placebo arm were diarrhea (22.0 percent vs. 22.6 percent), rash of any type (16.6 percent vs. 11.1 percent) and nausea (14.6 percent vs. 10.8 percent).

Important Safety Information

INTELENCE(TM) does not cure HIV infection or AIDS, and does not prevent passing HIV to others.

-- Severe and potentially life-threatening skin reactions, including

Stevens-Johnson Syndrome, hypersensitivity reaction, and erythema

multiforme, have occurred (<0.1 percent) in patients taking INTELENCE.

Treatment with
'/>"/>

SOURCE Tibotec Therapeutics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. FDA Advisory Committee Supports Efficacy and Safety of Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment
2. CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ(R) (atazanavir sulfate)/ritonavir and Twice-Daily lopinavir/ritonavir at 48 Weeks in Previously Untreated HIV-Infected Adult Patients
3. Nektar Commences Phase 2 Trial of NKTR-118 (oral PEG-naloxol) Evaluating Efficacy and Safety as Treatment for Opioid-Induced Bowel Dysfunction
4. New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies
5. Chroma Announces Positive Phase I Efficacy Data for Novel Cancer Therapy CHR-2797
6. Vanda Presents Phase III Iloperidone Efficacy Data
7. Long-Term Safety and Efficacy Data on Promacta(TM) (Eltrombopag) Presented at American Society of Hematology Annual Meeting
8. TREANDA Demonstrates Substantial Efficacy in Patients with Relapsed Indolent Non-Hodgkins Lymphoma
9. Biological Psychiatry Publishes Study Showing VYVANSE Demonstrated Significant Efficacy for Treatment of ADHD for up to 12 Hours After Administration
10. Powerful New Efficacy Data in Moderate and Severe Hypertensive Patients Supports FDA Approval of AVALIDE(R) (Irbesartan-Hydrochlorothiazide) as the First Combination Therapy for Initial Use in Patients Likely to Need Multiple Drugs to Achieve Their Blood
11. Ellex 2RT Study Demonstrates Clinical Efficacy in Treatment of Diabetic Macular Edema
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... MOUNT PROSPECT, Ill. , July 31, 2015 ... of Pharmacy ® (NABP ® ) issued ... charged with ensuring that action is taken against ... the Internet Drug Outlet Identification Program ... 2015 , thousands of websites ...
(Date:7/31/2015)... -- According to a new market research report ... Ethylene Oxide, Filtration, E-beam, Gamma), Services (Onsite & Offsite), Consumables ... Forecast to 2020", published by MarketsandMarkets, The Sterilization Equipment Market ... at a CAGR of 7.6%.from 2015 to 2020. ... ables and 37 F ...
(Date:7/31/2015)... -- Semler Scientific, Inc. (Nasdaq: SMLR ), a company ... and physician groups, today reported financial results for the ... "In the second quarter of 2015, Semler reported continued ... quarter over quarter revenue growth of 8%, and quarter ... units of 18%," said Doug Murphy-Chutorian, M.D., chief executive ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6
... Corporation (Nasdaq: DRRX ) today reported that King ... Inc. (Nasdaq: PTIE ) have announced that King ... the U.S. Food and Drug Administration (FDA) in response to ... 2008.  This is a Class 2 resubmission with a six ...
... During ICMS (International Cellular Medicine Society www.cellmedicinesociety.org ) ... Conference held on November 12, 2010 in Las Vegas, ... of diabetes gangrene recovered from foot ulcer through stem ... ) Patient, Sun Rae Cho (age 72 ...
Cached Medicine Technology:REMOXY® New Drug Application Resubmitted 2REMOXY® New Drug Application Resubmitted 3New Hope for Saving Diabetic Foot from Amputation 2
(Date:8/1/2015)... ... 01, 2015 , ... Calvary Hospital today announced that it is embarking on ... goal is to bring this Torah – dating from 1880 – back to kosher ... services. , Scroll No. 515, from the town of Taus-Domazlice, is on permanent ...
(Date:8/1/2015)... ... 2015 , ... On Tuesday, July 28th, Symantec released a security industry ... behind the attack on Anthem Inc. which resulted in one of the largest data ... and spear phishing campaigns. , For Joe Caruso, founder and CEO/CTO of ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – ... trek of the Appalachian Trail by stepping off Springer Mountain and heading north. ... On July 26th Phil reached Connecticut and was greeted by friends and family. He ...
(Date:7/31/2015)... (PRWEB) , ... August 01, 2015 , ... The Honor ... Global Advisory Panel on the Future of Nursing (GAPFON) 20-21 July 2015 in San ... to participate in this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by Becker’s Healthcare ... health analytics , Jvion continues to disrupt the predictive analytic and big data ... patient and population level illness to drive prevention and better health outcomes. Most ...
Breaking Medicine News(10 mins):Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2
... Oct. 31Like normal tissue, tumors thrive on nutrients carried ... of new blood vessels is a hallmark of cancer, ... can keep tumors from growing, too. To better understand ... would like to make detailed maps of the complete ...
... to popular belief, most college students don,t gain anywhere near ... nationwide study. Rather than adding "the freshman 15," as ... 2.5 and 3.5 pounds during the first year of college. ... gain, the study revealed. The typical freshman only gains about ...
... An international collaboration of scientists, including researchers at ... Skin Diseases (NIAMS), a part of the National ... that causes a rare childhood disease characterized predominantly ... that the disorder, named chronic atypical neutrophilic dermatosis ...
... hypertension (PAH) is a rare form of pulmonary hypertension (PH) that ... people out of one million people worldwide per year - most ... 40. While the numbers may not seem significant, the disease ... the causes of PAH remain unknown. As the ...
... , MONDAY, Oct. 31 (HealthDay News) -- Construction workers ... injuries and an increased risk of work-related illness and death, ... national sources and found that a construction worker has a ... 45-year career, and a 1-in-200 risk of being fatally injured ...
... by the Institute for Health Metrics and Evaluation (IHME) ... improved methods for analyzing verbal autopsies a method ... a complete vital registration system are fast, effective, ... to understand disease trends., While many high-income countries such ...
Cached Medicine News:Health News:The 'freshman 15' is just a myth, nationwide study reveals 2Health News:The 'freshman 15' is just a myth, nationwide study reveals 3Health News:NIH scientists discover link among spectrum of childhood diseases 2Health News:LA BioMed's Dr. Ronald Oudiz impacting lives of those with pulmonary hypertension 2Health News:'Hard Hats' Still Have High Rates of Injury, Illness: Report 2Health News:IHME develops fast, affordable ways for countries to better identify causes of death in populations 2Health News:IHME develops fast, affordable ways for countries to better identify causes of death in populations 3Health News:IHME develops fast, affordable ways for countries to better identify causes of death in populations 4
ISI DuraHand is the reusable, easy to sterilize surgical hand immobilizer....
MagPrep® Streptavidin Beads are encapsulated super-paramagnetic polystyrol particles coated with streptavidin. The beads have a diameter of 1 m and are provided as a stabilized aqueous suspensio...
For general purposes...
... is a method for isolating antibodies, ... cells using affinity binding, while retaining ... on the particles to separate biotinylated ... the MagnaBind™ Beads from the suspension, ...
Medicine Products: