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New 12 Week, Interferon-Free Treatment Arms Added to All-Oral Combination Study of PSI-7977 and Daclatasvir (BMS-790052) for HCV Genotype 1
Date:11/4/2011

PRINCETON, N.J., Nov. 4, 2011 /PRNewswire/ -- Pharmasset, Inc. (Nasdaq: VRUS) and Bristol-Myers Squibb Company (NYSE: BMY) announced today the addition of four treatment arms to the ongoing Phase IIa trial evaluating the combination of Pharmasset's PSI-7977, a nucleotide polymerase inhibitor, and Bristol-Myers Squibb Company's daclatasvir (BMS-790052), an investigational NS5A replication complex inhibitor, for the treatment of chronic hepatitis C (HCV).  This trial is the result of a clinical collaboration agreement between Pharmasset and Bristol-Myers Squibb announced in January 2011.

"Recent data from Pharmasset's ELECTRON trial as well as other all-oral DAA combination studies have demonstrated the potential of 12 week treatment regimens," stated William Symonds, Pharmasset's Senior Vice President of Clinical Pharmacology and Translational Medicine. "This study will evaluate whether the potent antiviral activity and high barrier to resistance seen in Phase II studies of PSI-7977 may enable shorter treatment durations with an interferon-free regimen than the current standard of care."

"Hepatitis C is a rapidly evolving field of research.  As the science evolves, we are evolving our clinical development programs to continue to drive advances in HCV research," said Brian Daniels, senior vice president, Development, Bristol-Myers Squibb.  "Shorter duration, all-oral therapy and effective treatment options for patients who have failed approved triple therapy regimens are clear unmet medical needs in HCV.  With this study, we aim to understand the potential for daclatasvir to help address these needs, as part of a novel combination treatment regimen."

About the Trial

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SOURCE Pharmasset, Inc.
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