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Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C
Date:7/22/2014

Bryostatin-1 for the treatment of Niemann-Pick Type C Disease as well as other lysosomal storage disorders," stated Dr. Ioannou.

"We are extremely pleased that Mount Sinai and Dr. Ioannou wish to participate in this important step in furthering the Company's strategic plan to be involved in orphan diseases which exhibit progressive loss of neurological functions," stated Paul Freiman and Charles S. Ramat, Neurotrope's Co-Chairmen and Co-Chief Executive Officers. "The submission of our joint provisional patent application further supports our belief in the therapeutic potential of bryostatin as an effective therapy in Alzheimer's and other neurodegenerative diseases."

Under the terms of the agreement, Neurotrope will pay Mount Sinai an up-front licensing fee, an annual maintenance fee and future payments based upon predetermined product development milestones. Furthermore, the Company will pay Mount Sinai a portion of consideration received from sub-licensees and a royalty on commercial net sales of products. The agreement was negotiated by Mount Sinai Innovation Partners which facilitates the real-world application and commercialization of Mount Sinai discoveries and the development of research partnerships with industry.

Dr. Ioannou is currently engaged with Neurotrope to provide compensated consultancy services.

About Niemann-Pick Type C Disease (NPC)

NPC is part of a group of inherited metabolic disorders known as lysosomal storage diseases.  Lipids (fatty materials such as waxes, fatty acids, oils, and cholesterol) and proteins are usually broken down into smaller components to provide energy for the body. In NPC, harmful quantities of lipids accumulate in the spleen, liver, lungs, bone marrow, and the brain. Symptoms may include lack of muscle coordination, brai
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SOURCE Neurotrope, Inc.
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