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Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C
Date:7/22/2014

PLANTATION, Fla., July 22, 2014 /PRNewswire/ -- Neurotrope Bioscience, Inc., a subsidiary of Neurotrope, Inc. (OTCQB: NTRP) has signed a world-wide, exclusive license agreement with the Icahn School of Medicine at Mount Sinai (Mount Sinai) to utilize its proprietary information and data package for the use of Bryostatin-1 in the treatment of Niemann-Pick Type C Disease (NPC), a rare disease, mostly of children who are afflicted with Alzheimer-like symptoms. The license also covers other diseases and disorders relying on activation of PKCepsilon, an enzyme which is important to the health of certain cells.

NPC is an orphan disease, defined by the U.S. Food and Drug Administration as a rare disease affecting fewer than 200,000 Americans, which will provide the drug developer with a seven-year period of U.S. marketing exclusivity if the drug: Is the first of its type approved for the specified indication, or; demonstrates superior safety or efficacy, or; provides a major contribution to patient care versus another drug of its type previously granted the designation for the same indication. In addition, orphan drug status provides company tax credits for clinical research costs, the ability to apply for annual grant funding, clinical research trial design assistance and waiver of Prescription Drug User Fee Act (PDUFA) filing fees.

This development program is being conducted in partnership with Dr. Yiannis Ioannou, Professor of Genetics and Genomic Sciences at Mount Sinai. In addition, the Company has applied, on behalf of itself and Mount Sinai, for a provisional patent with the U.S. Patent and Trademark Office to protect their ability to use and commercialize bryostatin technology for this disease indication.

"I am very excited to be working with Neurotrope on both the development of
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SOURCE Neurotrope, Inc.
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