Navigation Links
Neurologix Presents New Confirmatory Results for Phase 2 Study of NLX-P101 in Parkinson's Disease to Recombinant DNA Advisory Committee
Date:6/8/2011

ed from the hospital within 48 hours after the surgical procedure.

The primary outcome measure was the difference in UPDRS motor scores between NLX-P101 and sham-treated subjects, when the subjects were off PD medication. Other tests assessed motor fluctuations, constancy of medication effect and neuropsychological evaluations. A clinically-meaningful response was defined based on a 25 percent mean improvement from the initial Phase 1 NLX-P101 study (9 points). Patients in the sham surgery arm of the study who continue to meet all eligibility requirements will be provided an opportunity to receive NLX-P101 in a planned cross-over study. Treated subjects continue to be evaluated in an open-label, long-term follow-up study.

A Novel Approach to Gene Therapy

NLX-P101 aims to reset the overactive brain cells in the STN to inhibit electrical activity and return brain network activity to more normal levels. In PD, the loss of dopamine-secreting neurons alters chemical signaling pathways in the brain such that input to the STN is altered. The therapeutic approach with NLX-P101 modulates the activity of the STN (which is overactive in PD) by restoring GABA, a neurotransmitter important in STN function. GABA is made by a gene called glutamic acid decarboxylase (GAD). NLX-P101 uses an AAV vector (a disabled, non-pathogenic virus) to deliver the GAD gene into the STN. Increasing GAD activity causes more GABA to be synthesized, thus helping to lessen the STN over-activity.

About Parkinson's disease

Parkinson's disease is a progressive and debilitating neurodegenerative disorder that arises from the gradual deterioration of nerve cells in the brain. It affects the control of bodily movement and is characterized by four principal features: limb tremor, limb rigidity, bradykinesia (slowness of movement) and postural instability (trouble with balance).  

Parkinson's disease is typically a disease that affects people over
'/>"/>

SOURCE Neurologix, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. New Details Presented at the World Parkinson Congress on Neurologixs Successful Phase 2 Trial of Gene Therapy for Parkinsons Disease
2. Research Published in Science Translational Medicine Underscores Value of Depression Gene Therapy License Held by Neurologix
3. Neurologix Reports Third Quarter 2010 Financial Results
4. Neurologix Completes Additional $7 Million Financing
5. Neurologix Announces First Quarter 2011 Financial Results
6. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
7. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
8. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
9. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
10. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 2015 Zimmer Holdings, Inc. (NYSE and SIX: ... Advanced Bearing Technology with Vitamin E by celebrating a ... this month reported that, at 96 million cycles of ... Technology featuring Vitamin E grafted highly crosslinked polyethylene hip ... reduction of 95 percent, with no cracking, delamination or ...
(Date:3/26/2015)... -- Even the Score today marked this week,s 17 ... landmark approval of Viagra with the release of a ... the Agency to begin restoring gender equity in sexual ... most common sexual dysfunction. Currently, men have ... dysfunction – while women have zero biological treatment options ...
(Date:3/26/2015)... , March 26, 2015 ... and Drug Safety Software Market by Functionality (Adverse Event ... based (SAAS)), End-user (Pharma & Biotech Companies, CROs, ... MarketsandMarkets, the Pharmacovigilance and Drug Safety Software Market ... 6.5% during 2014-2019, and is expected to reach ...
Breaking Medicine Technology:Zimmer Announces New Testing Milestone For Vitamin E Advanced Bearing Technology 2Zimmer Announces New Testing Milestone For Vitamin E Advanced Bearing Technology 3Even The Score Marks 17th Viagra Anniversary with Release of New Letter from Members of Congress to FDA Calling for Equity in Sexual Health 2Even The Score Marks 17th Viagra Anniversary with Release of New Letter from Members of Congress to FDA Calling for Equity in Sexual Health 3Even The Score Marks 17th Viagra Anniversary with Release of New Letter from Members of Congress to FDA Calling for Equity in Sexual Health 4Pharmacovigilance and Drug Safety Software Market Worth $154.1 Million by 2019 2Pharmacovigilance and Drug Safety Software Market Worth $154.1 Million by 2019 3Pharmacovigilance and Drug Safety Software Market Worth $154.1 Million by 2019 4
... July 27, 2011 Reportlinker.com announces that ... in its catalogue: India ... Till 2016 http://www.reportlinker.com/p0575381/India-Cardiac-Catheters-and-Guidewires---Market-Trends-Till-2016.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Surgical_Equipment ... This market report provides vital ...
... 26, 2011 Symmetry Medical Inc. (NYSE: SMA ... orthopaedic device industry and other medical markets, announced today that ... period ending July 2, 2011 before the market opens on ... conference call at 8:00 a.m. ET on Thursday, August 4, ...
Cached Medicine Technology:India Cardiac Catheters and Guidewires - Market Trends Till 2016 2India Cardiac Catheters and Guidewires - Market Trends Till 2016 3Symmetry Medical to Report Second Quarter 2011 Financial Results on August 4, 2011 2
(Date:3/27/2015)... 2015 In light of two lawsuits ... U.S. District Court, District of Massachusetts; and case number ... of Pennsylvania), the San Diego personal injury lawyers of ... announcing that they are available to investigate potential ... were prescribed Zofran while pregnant and who gave birth ...
(Date:3/26/2015)... 26, 2015 Let’s not lose focus ... produce are today’s traffic magnets. Three out of 4 ... of their produce department, according to a Packaged Facts ... people are looking to add more fruits and vegetables ... Manager® Day is April 2. As featured in the ...
(Date:3/26/2015)... 2015 UC Davis will establish a ... origins of schizophrenia: A Silvio O. Conte Center for ... such centers in the United States. , The center ... the National Institutes of Mental Health, which will allow ... that an origin of schizophrenia may be dysregulation of ...
(Date:3/26/2015)... 26, 2015 Xarelto lawsuits ( ... with the issuance of new court documents in ... According to an Order dated March 24th, the ... Xarelto injury claims in the U.S. District Court, ... to file cases directly in the proceeding. (In ...
(Date:3/26/2015)... “The SWEET Act is an important step to invigorate the ... parents who are working to reduce sugar in their family ... public health, and we will continue to stand on the ... families,” said Dr. Jane Delgado President and CEO of the ... Sugar-Sweetened Beverage Tax (SWEET) Act by Congresswoman Rosa L. DeLauro. ...
Breaking Medicine News(10 mins):Health News:The Law Office of Melinda J. Helbock, A.P.C. Announces That It Is Now Accepting Case Reviews for Potential Zofran Birth Defect Lawsuits 2Health News:UC Davis Receives $10 Million Grant to Establish Center to Study Schizophrenia 2Health News:UC Davis Receives $10 Million Grant to Establish Center to Study Schizophrenia 3Health News:UC Davis Receives $10 Million Grant to Establish Center to Study Schizophrenia 4Health News:Xarelto Lawsuits Move Forward Nationwide, With Issuance of New Court Docs in State, Federal Litigations 2Health News:Xarelto Lawsuits Move Forward Nationwide, With Issuance of New Court Docs in State, Federal Litigations 3Health News:National Alliance for Hispanic Health Statement on Introduction of SWEET Act in 114th Congress 2
... the illness and depression, anxiety disorders, researchers say , ... of people with Parkinson,s disease are at increased risk ... The risk is particularly high in the brothers, sisters, ... age 75, said a team from the Mayo Clinic ...
... of Native American tribes, public health and environmental ... in,the U.S. Court of Appeals for the District ... that evade legally required cuts in,mercury pollution from ... broad coalition called for the complete reversal of ...
... Los,Angeles Jewish Home today broke ground on the first ... a decade, the newest in,California and the fastest-selling CCRC ... years after the city,s first senior housing was created ... to the number of,elderly residing in the region. Fountainview ...
... MOINES, Iowa, Dec. 6 A group of physicians ... appealing to both Democratic and,Republican candidates for President to ... highest quality hospitals, including their own., The appeal ... that was,prompted by threatened action by Senator Max Baucus, ...
... of Frutels, the Vitamin ... Gummy for Acne, ... principal of new business development consultancy BANKS., has,agreed to join Frutels, LLC ... years of executive marketing experience in apparel,cosmetics, fragrance and fashion accessories to ...
... to enhance care for Philadelphia Latinos, PHILADELPHIA, Dec. ... providing a total of $925,000 in funding through 2010,to ... of its,Charitable Medical Care Grant Program. The Grant program, ... that provide,free or low-cost health care to more than ...
Cached Medicine News:Health News:Relatives of Parkinson's Patients at Higher Psychiatric Risk 2Health News:EPA Plan to Evade Required Cuts in Mercury Pollution Challenged in Court by States, Tribes, Health and Environmental Groups 2Health News:Construction Begins on Los Angeles' First New Continuing Care Retirement Community Facility in Over a Decade 2Health News:Iowa-S. Dakota Physicians Appeal to Presidential Candidates: 'Help Defend America's Safest and Highest Quality Hospitals' 2Health News:Iowa-S. Dakota Physicians Appeal to Presidential Candidates: 'Help Defend America's Safest and Highest Quality Hospitals' 3Health News:Iowa-S. Dakota Physicians Appeal to Presidential Candidates: 'Help Defend America's Safest and Highest Quality Hospitals' 4Health News:Marketing Powerhouse Wendy Banks Joins Frutels' Advisory Board 2Health News:Independence Blue Cross Gives Grants to Support Health Care for the Uninsured 2
Pefakit PiCT UFH Controls...
Pefakit PiCT LMWH Controls...
Pefakit PiCT LMWH Calibrators...
Pefakit TAFI Calibrators and Controls...
Medicine Products: