Navigation Links
NeurogesX Reports First Quarter 2011 Results
Date:4/29/2011

SAN MATEO, Calif., April 29, 2011 /PRNewswire/ --

First Quarter 2011 Highlights:

  • Qutenza® (capsaicin) 8% patch purchased by 321 institutions, up from 239 in Q4 2010
  • Revenue of $3.2 million including $0.6 million U.S. Qutenza product revenue
  • Operational focus enables lower planned expense growth in 2011
  • Qutenza sales initiated in Poland and Czech Republic by Astellas
  • NGX-1998 Phase 2 clinical trial continues in postherpetic neuralgia (PHN) patients surpassing 65% enrollment

  • NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today reported results for its first quarter ended March 31, 2011.

    Anthony DiTonno, President and CEO, commented, "We are now one full year into the U.S. launch of Qutenza.  We made progress in our goal of creating awareness of Qutenza among our target physician groups and in establishing a base of Qutenza treatment sites from which to build.   As we move into our second year post launch, we are focusing our sales organization on growing the number of sites of care that can optimally utilize Qutenza and building patient awareness and increased physician usage."

    Qutenza Launch MetricsNeurogesX is executing the U.S. launch strategy for Qutenza by establishing a national network of Qutenza referral sites (QPROs) and continuing to expand marketing activities to reach patients treated in the primary care setting.  Key Qutenza launch metrics as of March 31, 2011 were as follows:

  • Qutenza on formulary or available without restriction in 137 institutions as of March 31, 2011, up from 102 at year end 2010
  • 321 institutions purchased Qutenza through first quarter 2011, an increase of 34% from 239 in the fourth quarter 2010
  • Percentage of repeat institutional customers grew to 60% of all institutional customers ordering in the first quarter 2011, up from 46% in fourth quarter 2010
  • The cumulative number of  private physician customers that have ordered Qutenza rose to 221 through March 31, 2011, up from 159 at December 31, 2010
  • Training activity continues with 1,535 physicians and institutions trained by March 31, 2011, up from 1,127 at December 31, 2010

  • First Quarter 2011 ResultsTotal revenue for the first quarter ended March 31, 2011 was $3.2 million, which consisted of $2.6 million in collaboration revenue, primarily from the amortization of upfront license fees received under the Astellas Agreement, and $0.6 million of Qutenza product sales.  

    During the three months ended March 31, 2011, the Company recorded sales of Qutenza to its specialty distribution and specialty pharmacy customers totaling $0.6 million. Under the Company's revenue recognition policy, the Company recognized revenue during the three months ended March 31, 2011 totaling $0.6 million.  

    Due to the limited history of product returns and cash collections, NeurogesX recognizes revenue at the later of the time the product is shipped by its customers to healthcare professionals and the date of cash collection.  As of March 31, 2011, the Company had $0.6 million of deferred product revenue.  Deferred revenue is reported net of associated cost of goods sold on the Company's balance sheet. Of the deferred revenue total, $0.4 million was sold through to end users (i.e., physicians, clinics and hospitals) and the deferral resulted from cash payments not yet being due under the payment terms, while $0.2 million represented deferral of sales into the Company's distribution channel, recognition of which will be based ultimately upon sales of those units to end users.

    Cost of goods sold for the first quarter 2011 totaled $0.1 million. Cost of goods sold includes product costs, fixed monthly charges related to the Company's third party logistics provider for warehousing, shipping activities, and royalty obligations due to intellectual property licensors.  

    Research and development expenses for the first quarter 2011 were $4.0 million, compared to $2.1 million in the year ago period.  The year-over-year change included increases of $0.9 million associated with the NGX-1998 Phase 2 study and $0.3 million of non-clinical research and development for NGX-1998. In the most recent period the Company recorded a $0.3 million increase in costs related to the planned supplemental NDA for Qutenza in the HIV-AN patient population.  

    Selling, General and Administrative (SG&A) expenses for the first quarter 2011 were $10.3 million, up from $8.8 million in the first quarter 2010.  In the first quarter of 2011, $1.8 million of the increase was due to a full quarter of salary and related expenses for the Company's sales organization, while in 2010 the sales organization staffing occurred late in the quarter,  and $0.9 million related to marketing events held in the first quarter of 2011.  These increases were partially offset by $1.2 million in lower marketing materials costs and $0.3 million in lower training costs, as the Company incurred significant pre-launch costs for Qutenza in the first quarter of 2010.

    Net loss for the first quarter 2011 was $13.4 million, or $0.75 per share, compared to a net loss of $9.2 million, or $0.52 per share, for the first quarter 2010.  

    Cash, cash equivalents and short-term investments were $34.7 million at March 31, 2011, compared to $46.8 million at December 31, 2010.

    Stephen Ghiglieri, EVP, COO and CFO, commented, "In the last month, we reassessed our spending levels and narrowed our focus in a number of operational areas including  a refocusing of our sales organization on larger institutions and large private practices who can become QPRO sites.  These initiatives allowed us to moderate planned spending growth and as a result, we have reduced our planned operating expenses for 2011 by approximately 14% from prior guidance.  Our 2011 operating expenses are now expected to be in the range of $50 million to $53 million.  Our primary focus remains on ensuring the continued adoption of Qutenza, recognizing the longer term nature of the investments necessary for success.  Other key activities include submission of a supplemental NDA for Qutenza for the management of neuropathic pain associated with HIV-associated neuropathy (HIV-AN) as well as advancing the clinical development of NGX-1998, our topical liquid formulation containing a high concentration capsaicin.  With our reduced expenses and continued focus on our key operational initiatives, we continue to pursue opportunities to increase our capital."  

    Investor DayNeurogesX will host an investor day today from 8:15 am - 11:00 am EDT at The New York Palace Hotel in New York.  As part of the presentation, management will review results for the first quarter ended March 31, 2011.  The Company will provide an update on the US launch of the Qutenza® (capsaicin) 8% patch and on the development of NGX-1998. The Investor Day will be webcast live and archived for 30 days on the investor relations section of the NeurogesX website at www.neurogesx.com.

    About NeurogesX, Inc.NeurogesX, Inc. (Nasdaq: NGSX) is a San Francisco Bay Area-based biopharmaceutical company focused on developing and commercializing novel pain management therapies. NeurogesX was founded on the concept that use of prescription-strength capsaicin could help manage the pain associated with neuropathic pain conditions. Since its inception, NeurogesX has leveraged its passion to help people with pain to efficiently develop this concept, resulting in the commercial launch of Qutenza® (capsaicin) 8% patch in 2010. The Company continues to apply its knowledge and expertise in the development of other novel treatments for pain.

    The Company's lead product, Qutenza, is a localized dermal delivery system containing prescription strength capsaicin that is currently approved in the United States and the European Union. Qutenza is now available in the United States for the management of neuropathic pain associated with postherpetic neuralgia (PHN). In Europe, Qutenza is being marketed by Astellas Pharma Europe Ltd. (Astellas), the European subsidiary of Tokyo-based Astellas Pharma Inc., for the treatment of peripheral neuropathic pain in non-diabetic adults, either alone or in combination with other medicinal products for pain.

    The Company is currently preparing to submit a supplemental new drug application (sNDA) to expand the U.S. label for Qutenza for the management of pain due to HIV-associated neuropathy (HIV-AN) also known as HIV-distal sensory polyneuropathy (HIV-DSP).

    The Company's most advanced product candidate, NGX-1998, is a topically applied liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions such as PHN. NGX-1998 has completed three Phase 1 studies and patient dosing is underway in a Phase 2 clinical trial in PHN patients.

    The Company's early-stage pipeline includes pre-clinical compounds which are prodrugs of acetaminophen and various opioids. The Company has evaluated certain of these compounds in vitro and in vivo.

    Safe Harbor Statement This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the Act). NeurogesX disclaims any intent or obligation to update these forward-looking statements, and claims the protection of the Safe Harbor for forward-looking statements contained in the Act. Examples of such statements include but are not limited to: statements regarding expectations regarding the submission of the supplemental new drug application for label expansion of Qutenza, expectations regarding the Company's Phase 2 clinical trial of NGX-1998 and expected operating expenses, including moderated expense growth, for 2011.  Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to: difficulties or delays in the commercialization of Qutenza, including with respect to the successful marketing or manufacture and supply of Qutenza; physician or patient reluctance to use Qutenza, despite efforts and strategies to commercialize Qutenza; difficulties or delays in the further development of Qutenza for additional indications, including difficulties or delays in the submission of the sNDA for Qutenza; and difficulties or delays in the clinical development of NGX-1998.  For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission. NEUROGESX, INC.Condensed Consolidated Statements of Operations(in thousands, except share and per share information)Three Months EndedMarch 31,20112010 Net product revenue

    $
    575$
    8212; Collaboration revenue

    2,5951,786Total revenue

    3,1701,786Operating expenses:Cost of goods sold

    108—Research and development

    3,9572,123Selling, general and administrative

    10,2828,806Total operating expenses

    14,34710,929Loss from operations

    (11,177)(9,143)Interest income

    278Interest expense

    (2,200)(4)Other income (expense), net

    (13)(24)Net loss

    $
    (13,363)$
    (9,163)Basic and diluted net loss per share$
    (0.75)$
    (0.52)Shares used to compute basic and diluted net loss per share

    17,870,34717,726,153NEUROGESX, INC. Condensed Consolidated Balance Sheets (in thousands) March 31,2011December 31,2010Assets(Note 1)Current assets:Cash and cash equivalents

    $
    4,240

    $
    8,705Short-term investments

    30,463

    38,125Trade receivable

    623

    607Receivable from collaboration partner

    98

    65Inventories

    768

    786Prepaid expenses and other current assets

    1,770

    1,082Restricted cash

    290

    290Total current assets

    38,252

    49,660Property and equipment, net

    774

    809Restricted cash

    120

    120Other assets

    253

    261Total assets

    $
    39,399

    $
    50,850Liabilities and Stockholders' DeficitCurrent liabilities:Accounts payable

    $  1,674

    $  1,544Accrued compensation

    1,506

    1,867Accrued research and development

    821

    582Other accrued expenses

    4,173

    3,011Deferred product revenue, net

    563

    577Deferred collaboration revenue

    7,261

    7,242Long term obligations—current portion

    2,605

    2,222Total current liabilities

    18,603

    17,045Non-current liabilities:Deferred collaboration revenue

    30,554

    32,359Deferred rent

    67

    115Long term obligations

    44,230

    42,622Total non-current liabilities

    74,851

    75,096Commitments and contingencies Stockholders' deficit:Common stock, $0.001 par value

    18

    18Additional paidin capital

    215,806

    215,220Accumulated other comprehensive gain (loss)

    11

    (2)Accumulated deficit

    (269,890)

    (256,527)Total stockholders' deficit

    (54,055)

    (41,291)Total liabilities and stockholders' deficit

    $  39,399

    $  50,850(Note 1) Derived from the audited consolidated financial statements as of December 31, 2010.NeurogesX, Inc.Stephen Ghiglieri

    Executive Vice President, COO

    and CFO

    (650) 358-3310The Ruth GroupStephanie Carrington (investors)

    (646) 536-7017

    scarrington@theruthgroup.com Jason Rando (media)

    (646) 536-7025

    jrando@theruthgroup.com
    '/>"/>

    SOURCE NeurogesX, Inc.
    Copyright©2010 PR Newswire.
    All rights reserved

    Related medicine technology :

    1. NeurogesX Receives Notice of Allowance for Patent Covering NGX-1998 Capsaicin Topical Liquid
    2. NeurogesX Reports Fourth Quarter and Year-End 2010 Results
    3. NeurogesX to Provide Qutenza® Launch Update
    4. NeurogesX to Present at Two February Investor Conferences
    5. NeurogesX Receives Qutenza®-Specific J-Code From Centers for Medicare and Medicaid Services (CMS)
    6. NeurogesX Doses First Patient in Phase 2 Clinical Study of NGX-1998 Liquid Capsaicin Formulation
    7. NeurogesX to Hold Conference Call to Discuss Third Quarter 2010 Results
    8. NeurogesX to Present at Oppenheimer & Co Healthcare Conference
    9. Although NeurogesX/Astellass Qutenza is Only Approved for Postherpetic Neuralgia, Surveyed U.S. Physicians are Likely to Prescribe It for All Neuropathic Pain Types
    10. NeurogesX Appoints Seasoned Sales and Marketing Executive as New Board Director
    11. NeurogesX Receives FDA Approval of Qutenza(TM) (capsaicin) 8% Patch for Treatment of Postherpetic Neuralgia (PHN)
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
    (Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
    (Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
    Breaking Medicine Technology:
    (Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
    (Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
    (Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
    (Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
    (Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
    Breaking Medicine News(10 mins):