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NeurogesX Announces Positive Results from Second Phase 3 Clinical Trial in Postherpetic Neuralgia
Date:9/4/2007

tp://www.neurogesx.com. A web cast replay can be accessed on the Company's web site beginning September 4, 2007, at approximately 2:30 p.m. The replay will remain available until September 19, 2007.

About NGX-4010

NGX-4010 is a non-narcotic, locally-acting analgesic formulated in a topical patch containing the TRPV1 agonist -- synthetic capsaicin. Capsaicin is released from the patch and absorbed into the skin without significant absorption into the bloodstream. Accordingly, users of NGX-4010 may be able to avoid the systemic side effects of anti-convulsants, anti-depressants and opioids, including sedation and the potential for abuse and addiction associated with some of these drugs. NGX-4010 is administered in a physician's office in a non-invasive process that involves pre-treating the painful area with a topical anesthetic followed by the application of the patch. In three Phase 3 clinical trials, NGX-4010 has been shown to provide a clinically meaningful reduction in peripheral neuropathic pain for up to 12 weeks.

About PHN and HIV-DSP

PHN is a painful condition affecting sensory nerve fibers. It is a complication of shingles, a second outbreak of the varicella-zoster virus, which initially causes chickenpox. Following an initial infection, some of the virus can remain dormant in nerve cells. Years later, age, illness, stress, medications or other factors that are not well understood can lead to reactivation of the virus. The rash and blisters associated with shingles usually heal within six weeks, but some people continue to experience pain for years thereafter. This pain is known as postherpetic neuralgia. PHN may occur in almost any area, but is especially common on the torso.

According to the Centers for Disease Control (CDC), there are approximately 1.0 million cases of shingles in the United States each year, and approximately one in five develop PHN. According to Jain BioPharma, in 2005 there were approximately 500,000 p
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SOURCE NeurogesX, Inc.
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