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Neurobiological Technologies, Inc. and Buck Institute Partner to Develop Novel Treatment for Alzheimer's Disease
Date:3/3/2008

EMERYVILLE and NOVATO, Calif., March 3 /PRNewswire-FirstCall/ -- Neurobiological Technologies, Inc. (Nasdaq: NTII) and the Buck Institute for Age Research (Buck) announced today they have entered into a collaboration and exclusive license agreement to develop a novel therapy for Alzheimer's Disease (AD). Under the terms of the agreement Neurobiological Technologies will exclusively license certain patent rights related to a naturally occurring protein that has been shown in animals to reverse the symptoms of Alzheimer's disease.

AD is a neurodegenerative disease that, in its most common form, occurs in people over 65 years old and is the most common cause of dementia afflicting 24 million people worldwide.

AD Research at the Buck Institute focuses on signal transduction pathways that may explain all of the different, yet seemingly opposed theories of AD, namely that AD is caused by either an overabundance of amyloid-B (AB) peptide, or neurofibrillary tangles that build up inside the nerve cells. Current studies at the Buck are focused on a naturally occurring protein that has been shown in both cell culture and mice to inhibit the production of amyloid-B (AB) peptides while simultaneously facilitating the growth and preservation of nerve fibers in the brain.

As part of this agreement, Neurobiological Technologies has agreed to fund a joint research collaboration with the Buck relating to the Alzheimer's drug development for up to three years. Research funding for the initial year under the Agreement will total $1.2 million. In consideration for the license, Neurobiological Technologies will pay upfront license fees totaling $175,000 over a three-year period.

"The partnership with the Buck Institute has the pote
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SOURCE Neurobiological Technologies, Inc.; Buck Institute for AgeResearch
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