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NeuroSigma Subsidiary Acquires Thin-Film Nitinol Fabrication Patent Portfolio
Date:5/16/2012

LOS ANGELES, May 16, 2012 /PRNewswire/ -- NeuroSigma, Inc., a Los Angeles-based medical device company, today announced that its majority-owned subsidiary, NSVascular, Inc. (NSV), acquired a portfolio of patents and related trade secrets covering the fabrication of Thin-Film Nitinol (TFN) from TiNi Alloy Company, including U.S. Patent No. 6,746,890 entitled "Three Dimensional Thin Film Devices and Methods of Fabrication," an important piece of the portfolio covering the production of three-dimensional TFN constructs.

NSV was formed in 2011 to commercialize TFN-covered stent technology, exclusively licensed from the University of California, Los Angeles (UCLA).  Nitinol is a superelastic nickel and titanium alloy with unique properties that allow deformation and subsequent recovery of the full shape upon exposure to body heat. NSV is initially focused on developing and commercializing TFN-covered stents for endovascular applications, with its most advanced product being a flow-diverting stent for treating intracranial aneurysms.  The unique properties of TFN allow for the fabrication of stents that can be compressed and inserted into vessels through very small catheters, a necessity for endovascular technologies being used in the brain.

Intracranial aneurysms result from weaknesses in cerebral blood vessels, which can rupture; potentially leading to stroke and death. It is estimated that up to one in fifteen Americans will develop an intracranial aneurysm in their lifetime. Current endovascular techniques for treating this condition include placing small coils inside the aneurysm sac. While the procedure is effective, it can be time-consuming and the aneurysms are prone to recurrence.

In contrast, flow-diverting stents may offer a simpler and more permanent solution, whereby a minimally-invasive catheter is used to insert the device into the blood vessel over the neck of the aneurysm, resulting in diversion of blood away from
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SOURCE NeuroSigma, Inc.
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