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NeuroSigma Receives Global Quality Control Certification
Date:7/2/2012

ce at the UCLA School of Medicine's Department of Psychiatry, where he serves as Director of the UCLA Depression Research and Clinic Program.

"As a novel and non-invasive therapy, trigeminal nerve stimulation may represent a paradigm shift in the way we treat major depression, post-traumatic stress disorder (PTSD), and epilepsy, and offers the potential to significantly improve the lives of millions of people without the side-effects common to drug treatment," said Dr. Ian Cook.

"All of us at NeuroSigma are excited that the groundbreaking research of these eminent physicians is coming closer to becoming commercially available to doctors and their patients as an external and drug-free alternative to current therapies," said Leon Ekchian, Ph.D., President and CEO of NeuroSigma.  "We have received an increasing number of inquiries from the public as they become aware of eTNS via sources such as the recent article in the Daily Mail in the United Kingdom."

Background - TNS

NeuroSigma is commercializing two embodiments of trigeminal nerve stimulation (TNS): eTNS™ (external electrodes and an external pulse generator) and sTNS™ (subcutaneous electrodes and implantable pulse generator).  The eTNS system utilizes a self-adhesive conductive pad applied to the forehead to stimulate branches of the trigeminal nerve, which are located very close to the surface of the skin in the forehead.  The trigeminal nerve is the largest cranial nerve, offering a high-bandwidth pathway for signals to enter the brain.  In clinical studies, eTNS is well tolerated and the low-energy stimulus is confined to the soft tissues of the face without direct penetration into the brain – hence the term "USB Port to the Brain™."

The trigeminal nerve projects to specific areas of the brain, such as the locus coeruleus
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