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NeuroDerm Announces Positive Results of a Phase II Study of ND0611 Dermal Patch in Patients with Parkinson's Disease
Date:11/9/2011

for each oral treatment mode were evaluated separately and showed statistical significance.

This trial was supported by a grant of $1 million  by The Michael J. Fox Foundation for Parkinson's Research as part of the Foundation's Clinical Intervention Awards 2010 program.

About Parkinson's Disease

Parkinson's disease affects approximately 6 million patients in the world. It is caused by decreasing dopamine signaling in the brain as dopaminergic brain cells die off. Levodopa is the "Gold Standard" therapy for Parkinson's disease, and virtually all patients receive it. Levodopa is always co-administered with a degradation inhibitor (usually, carbidopa). When administered through the oral route, however, levodopa suffers from a short clearance half-life and low bioavailability that contributes to motor complications in Parkinson's patients.

About ND0611

ND0611 is based on a proprietary formulation that enables, for the first time, the continuous administration of carbidopa in a practical manner via a subcutaneous dermal patch. Carbidopa, conventionally co-administered with levodopa orally to prevent its breakdown, suffers from low bioavailability in itself. Continuous subcutaneous delivery of carbidopa should thus improve the bioavailability of oral levodopa, permit more continuous levels of levodopa to be maintained in the brain, improve the management of motor fluctuations in Parkinson's disease patients and result in a more efficacious usage of levodopa in Parkinson's disease therapy.

About NeuroDerm

NeuroDerm is an emerging pharmaceutical company that develops therapies for the treatment of CNS diseases. NeuroDerm's technology is based on proprietary reformulations of well established oral drugs whose low bio-availability is the major impediment to better efficacy. The company's lead products are ND0611, a revolutionary skin patch for the treatment of Parkinson's disease and ND0801, a combination patch for the tr
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SOURCE NeuroDerm Ltd
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