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Neuraltus Pharmaceuticals Reports Clinical Results from Phase 1/2 NP002 Study in the Treatment of Dyskinesias Resulting from Levodopa Therapy for Parkinson's Disease
Date:12/3/2010

es, statistical superiority of NP002 over placebo were observed in a variety of physician- and patient-rated PD efficacy outcome measures relating to dyskinesias.

Abraham Lieberman, MD, the study's principal investigator and Director of the Muhammad Ali Parkinson's Center, commented, "NP002 represents an innovative approach to a common side effect in treating Parkinson's disease and has opened up new ideas on how to approach dyskinesias.  The early study results of NP002 in patients with Parkinson's show promising trends in reducing dyskinesias and in improving gait.  I am encouraged by these results and believe they provide a key piece in understanding and addressing the mechanism of dyskinesias in many of our patients with Parkinson's disease."

J. William Langston, MD, Founder, CEO and Scientific Director of the Parkinson's Institute, stated, "It's impressive that the NP002 study data were encouraging across several scales used to measure dyskinesias.  In particular, the study showed a significant trend in improvement in the objective UDRS scale and statistically significant results on the PGIC scale, which measures how patients feel overall, suggesting an improvement in quality of life.  We are very excited to see this work progress to Phase 2 trials based on these encouraging data."

Carrolee Barlow, MD, PhD, CSO and CMO of BrainCells, Inc., and scientific advisor to Neuraltus on the NP002 program, stated, "Patients with Parkinson's disease currently have no therapeutic options to address the dyskinesias caused by levodopa treatment.  The clinical study demonstrated a clinically important improvement in dyskinesia symptoms that could be detected by both clinicians and patients.  The data are compelling and provide a breakthrough for this condition."

The Phase 1/2 data are the second clinical program results reported by Neuraltus this week, following announcement of clinical results for NP001, which showed
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SOURCE Neuraltus Pharmaceuticals, Inc.
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