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Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS
Date:3/9/2009

he potency of our cells to address progressive neurological degenerations."

In a study conducted at Johns Hopkins Medical Institutions, laboratory-grown human neural stem cells (hNSCs) isolated from a fetal spinal cord region were grafted into the spinal cord of rats with a genetic mutation (SOD-1 G93A) that gives them a disease like a particularly aggressive form of ALS. These rats received live-cell grafts or dead-cell grafts as controls. In addition, four healthy rats (Spague-Dawley) received live-cell grafts to rule out whether or not any cell activity could be attributed solely to ALS in the SOD-1 rats. The rats had been injected with a tracing material to track and characterize the synaptic connections. 40 days after transplantation, the tissues were examined. In the rats receiving live-cell grafts, a large number of host motor neurons had been contacted by human neurons differentiated from the grafted neural stem cells. This occurred in both the ALS model and healthy rats, indicating that the activity was not a result of the disease. The study can be found at:

http://www3.interscience.wiley.com/journal/117928903/grouphome/home.html

"This study shows, at the ultra-structural level, that these cells make mature connections with host motor neurons in the spinal cord," said Dr. Vassilis E. Koliatsos, whose lab at Johns Hopkins conducted the study. "This demonstrates that these cells not only live, but integrate into the structure of the host's motor system. It also confirms our previous suspicion that many neural stem cells become inhibitory local neurons in the spinal cord."

About Neuralstem

Neuralstem's patented technology enables, for the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to contro
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SOURCE Neuralstem, Inc.
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