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Neupro® (Rotigotine) Provided Clinically Relevant Improvements in Health-Related Quality of Life for People with Parkinson's Disease
Date:9/30/2010

line recording, the study compared the effects of rotigotine administered as a slow-release formulation of 0.5 or 5 mg/kg every second day for 6 days and L-DOPA/benserazide administered daily at 10/7.5 mg/kg s.c., for 6 days in 6-OHDA lesioned rats.

Latency to slow wave sleep (SWS) and paradoxical sleep (REM) onset, duration of waking, SWS and REM sleep and the alpha and delta frequency ratio during SWS were analyzed off-line. No effects were seen with low dose rotigotine or with a placebo vehicle. Pulsatile L-DOPA and continuous rotigotine at 5 mg/kg caused an increase in active waking and a decrease in SWS duration. While L-DOPA had no effect on the alpha/delta power ratio, the high dose of continuous rotigotine decreased the alpha/delta ratio towards an increase in delta power during SWS.

Other UCB sponsored presentations at the 2nd World Parkinson CongressFresh insights into the lives of people living with Parkinson's disease, and their differing needs for information and support were reported in analyses sponsored by UCB and presented at the Congress:

  • Lindvall S, Graham L, O'Brien E, Davis U. A Qualitative Assessment of the Educational and Support Needs of People Living with Parkinson's Disease
  • Verhaeghe A. & Elleboudt L. Learning from Online Discussions about Parkinson's Disease Amongst People with Parkinson's and Their Carers
  • Wullner U, Fuchs G, Reketat N, Randerath O, Kassubek J. Pharmacotherapy for Parkinson's Disease — Patients' Priorities

  • Data from a retrospective cohort study, also presented at the Congress, investigated the clinical and health economic impact of gastrointestinal disorders in patients with Parkinson's disease:

  • Richy F, Gunn A, Makaroff L, Gervasoni C, Helmers S. Disorders in Patients with Parkinson's Disease (PD): A Double-Edged Sword

  • For further informationEimear O Brien, Associate Director, Global CNS CommunicationsT +32 2 559 9271, <
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    SOURCE UCB
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