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Neupro(R) (Rotigotine Transdermal System) Effective in Controlling Early Morning Motor Impairment and Generally Well-Tolerated for Long-Term Use in Patients with Parkinson's Disease
Date:10/8/2007

plied to the skin once a day and provides rotigotine continuously to the body for 24 hours. Patients receiving Neupro(R) initiate treatment with a 2 mg/24 hours patch and titrate in 2 mg/24 hours increments each week until the optimal effect is observed, up to a maximum dose of 6 mg/24 hours. The administration of Neupro(R) offers simple, once-daily dosing, and it is easy to use.

Neupro(R) is approved in the United States for the treatment of the signs and symptoms of early-stage idiopathic Parkinson's disease, and in Europe for the treatment of patients with early Parkinson's disease and in combination with levodopa for advanced Parkinson's disease.

About Parkinson's Disease

Parkinson's disease is a progressive disorder of the central nervous system. The patients -- roughly four million worldwide, including approximately one million people in the United States -- suffer primarily from a lack of dopamine, a messenger substance in the central nervous system, which is responsible for the coordination of movement. As a result of this shortage, patients are no longer able to control their movements reliably. Dopamine agonists are drugs that attempt to compensate for this lack of dopamine.

Important Safety Information

Neupro(R) is indicated for the treatment of the signs and symptoms of early-stage idiopathic Parkinson's disease. Some patients treated with Neupro(R) reported falling asleep while engaged in activities of daily living, including operation of motor vehicles, which sometimes resulted in accidents. Some patients perceived no warning signs, such as excessive drowsiness. Hallucinations were reported in 2.0% of patients treated with Neupro(R) compared to 0.7% of patients on placebo. Neupro(R) should be used with caution in patients, especially those at risk for cardiovascular disease, because of the potential for symptomatic hypotension, syncope, elevated heart rate, elevated blood pressure, fluid retention, and/or weight gain. All
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SOURCE UCB, Inc.
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